Synthesis of the four d,l-pairs of 2-amino-3-phenylnorbornane-2-carboxylic acids II. The use of 5(4H)-oxazolones as dienophiles.
1993; Elsevier BV; Volume: 49; Issue: 3 Linguagem: Inglês
10.1016/s0040-4020(01)86269-4
ISSN1464-5416
AutoresCarlos Cativiela, María D. Díaz‐de‐Villegas, José A. Mayoral, Alberto Avenoza, Jesús M. Peregrina,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoThe Diels-Alder reaction between both geometric isomers (Z)- or (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone and cyclopentadiene is studied. The cycloadducts are converted into the aminoacids through simple reactions allowing the synthesis of the four d,l-pairs of 2-amino-3-phenylnorbornane-2-carboxylic acids.
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