Spread of chloroquine resistance in Plasmodium falciparum
1987; Elsevier BV; Volume: 3; Issue: 8 Linguagem: Inglês
10.1016/0169-4758(87)90147-5
ISSN1873-1473
Autores Tópico(s)Computational Drug Discovery Methods
ResumoMalaria resistant to chloroquine has now been confirmed in more than 40 countries. The drug was introduced in 1934, but was not in large-scale use until the early 1950s. Anecdotal reports suggest that resistance emerged as early as 1957 both in Colombia and along the then Cambodia-Thailand border area. But by 1960, resistance in these areas was confirmed — and may represent two separate events. Resistance spread rapidly, with a new focus of resistance confirmed in East Africa by 1977. Chloroquine resistance represents a severe problem both for prophylaxis and treatment of malaria. In this aricle, David Payne traces the spread of resistance and discusses some of its implications.
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