Catalytic asymmetric nitroaldol reaction: An efficient synthesis of (S) propranolol using the lanthanum binaphthol complex
1993; Elsevier BV; Volume: 34; Issue: 5 Linguagem: Inglês
10.1016/0040-4039(93)89031-k
ISSN1873-3581
AutoresHiroaki Sasai, Noriie Itoh, Takeyuki Suzuki, Masakatsu Shibasaki,
Tópico(s)Synthetic Organic Chemistry Methods
Resumo(S) Propranolol, a more potent optical isomer of the widely used β-blocker, was conveniently synthesized in a higly enantioselective manner by the lanthanum-(R)-(+)-binaphthol complex catalyzed asymmetric nitroaldol reaction.
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