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Multiple Myeloma in Three Siblings

1985; American Medical Association; Volume: 145; Issue: 8 Linguagem: Inglês

10.1001/archinte.1985.00360080123018

1538-3679

Leonard Horwitz,

Lymphoma Diagnosis and Treatment

All three siblings of a family developed multiple myeloma. Two siblings had a history of monoclonal gammopathy; in one of these two siblings and in the third sibling, the disease progressed rapidly. A review of the literature shows that of 38 previously reported pairs of siblings with plasma cell disorders, eight families had a third affected sibling and four another affected relative. This clinical clustering suggests that some cases of multiple myeloma may have a hereditary basis and that other family members may be at risk for developing the disease.