Portal de Periódicos da CAPES

Toxicologic changes in rats fed graded dietary levels of ochratoxin A

1974; Elsevier BV; Volume: 28; Issue: 2 Linguagem: Inglês

10.1016/0041-008x(74)90003-9

1096-0333

I.C. Munro, C.A. Moodie, T. Kuiper‐Goodman, Peter Scott, H. C. Grice,

Carcinogens and Genotoxicity Assessment

In a short-term study, groups of weanling male rats were fed a semipurified diet containing 0, 2.4, 4.8, 9.6 or 24 ppm of ochratoxin A for a period of 2 weeks. Growth retardation and reduced food consumption were observed in rats fed 9.6 or 24 ppm but not in those fed 2.4 or 4.8 ppm of the compound. Rats fed 24 ppm of ochratoxin A had elevated serum blood urea nitrogen (BUN) values and significantly increased kidney weights accompanied by marked degenerative changes involving the entire tubular system. Similar, but less extensive, changes were noted in the 4.8 and 9.6 ppm groups. In a subacute study groups of 15 weanling male and female rats were fed a semipurified diet for 90 days containing 0, 0.2, 1.0 or 5.0 ppm of ochratoxin A. Body weight was significantly reduced in the 5.0 ppm group. In contrast to the short-term study, relative kidney weights were reduced in the 1.0 and 5.0 ppm groups, and the latter group had elevated BUN values. Dose-related pathologic changes were noted in the kidneys of all treated rats. In the 0.2 ppm group a few scattered cells in the proximal convoluted tubules underwent granular eosinophilic degeneration, and a few cells developed bizarre giant nuclei. At the higher doses, similar, but more extensive changes were observed.