Suppression of experimental autoimmune encephalomyelitis with a TNF binding protein (TNFbp) correlates with down-regulation of VCAM-1/VLA-4
1998; Wiley; Volume: 28; Issue: 6 Linguagem: Inglês
10.1002/(sici)1521-4141(199806)28
ISSN1521-4141
AutoresKrzysztof Selmaj, Agata Walczak, Marcin P. Mycko, Tomasz Berkowicz, Tadahiko Kohno, Cedric S. Raine,
Tópico(s)Immune Response and Inflammation
ResumoEuropean Journal of ImmunologyVolume 28, Issue 6 p. 2035-2044 ArticleFree Access Suppression of experimental autoimmune encephalomyelitis with a TNF binding protein (TNFbp) correlates with down-regulation of VCAM-1/VLA-4 Krzysztof Selmaj, Krzysztof Selmaj Department of Neurology Medical Academy of Lodz, Lodz, PolandSearch for more papers by this authorAgata Walczak, Agata Walczak Department of Neurology Medical Academy of Lodz, Lodz, PolandSearch for more papers by this authorMarcin Mycko, Marcin Mycko Department of Neurology Medical Academy of Lodz, Lodz, PolandSearch for more papers by this authorTomasz Berkowicz, Tomasz Berkowicz Department of Neurology Medical Academy of Lodz, Lodz, PolandSearch for more papers by this authorTadahiko Kohno, Tadahiko Kohno Amgen Inc., 3200 Walnut Street, Boulder, USASearch for more papers by this authorCedric S. Raine, Cedric S. Raine Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, USASearch for more papers by this author Krzysztof Selmaj, Krzysztof Selmaj Department of Neurology Medical Academy of Lodz, Lodz, PolandSearch for more papers by this authorAgata Walczak, Agata Walczak Department of Neurology Medical Academy of Lodz, Lodz, PolandSearch for more papers by this authorMarcin Mycko, Marcin Mycko Department of Neurology Medical Academy of Lodz, Lodz, PolandSearch for more papers by this authorTomasz Berkowicz, Tomasz Berkowicz Department of Neurology Medical Academy of Lodz, Lodz, PolandSearch for more papers by this authorTadahiko Kohno, Tadahiko Kohno Amgen Inc., 3200 Walnut Street, Boulder, USASearch for more papers by this authorCedric S. Raine, Cedric S. Raine Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, USASearch for more papers by this author First published: 28 March 2006 https://doi.org/10.1002/(SICI)1521-4141(199806)28:06 3.0.CO;2-ACitations: 28AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The effect of a novel TNF binding protein (TNFbp), a polyethylene glycol-linked form of the type I soluble receptor of TNF, on the expression of adhesion molecules has been investigated with a passive transfer model of experimental autoimmune encephalomyelitis (EAE) in SJL/J mice. The expression of L-selectin, VLA-4 and LFA-1 on spleen cells of EAE animals treated with TNFbp or saline was examined by FACS analysis. The expression of VCAM-1 and ICAM-1 was investigated by immunochemistry in spinal cord tissue of SJL/J mice with EAE. In animals sensitized for EAE and treated with TNFbp, the expression of VCAM-1 in the central nervous system as well as VLA-4 on spleen cells was clearly diminished. Reduction in VCAM-1 staining and VLA-4 expression corresponded to inhibition of inflammation in the spinal cord and to prevention of clinical signs of EAE. The results have also shown that myelin basic protein responses as well as non-antigen-specific responses were not diminished in animals treated with TNFbp. The findings suggest that TNFbp might prevent EAE development by modulating the expression of VCAM-1 and VLA-4. Citing Literature Volume28, Issue6June 1998Pages 2035-2044 ReferencesRelatedInformation
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