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Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

2014; Elsevier BV; Volume: 123; Issue: 15 Linguagem: Inglês

10.1182/blood-2013-07-511683

1528-0020

Loveena Rishi, Maura Hannon, Mara Salomè, Marie Sigurd Hasemann, Anne-Katrine Frank, Joana Campos, Jennifer Timoney, Caitríona O’Connor, Mary R. Cahill, Bo Porse, Karen Keeshan,

Histone Deacetylase Inhibitors Research

Key Points E2F1 regulates Trib2 expression and C/EBPα modulates E2F1-induced Trib2 activity at the granulocyte macrophage progenitor stage. Pharmacological inhibition of the cell cycle resulting in a block in E2F1 or Trib2 knockdown abrogates AML cell proliferation.