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Electrophilic 18F from a siemens 11 MeV proton-only cyclotron

1995; Elsevier BV; Volume: 22; Issue: 1 Linguagem: Inglês

10.1016/0969-8051(94)e0064-p

1872-9614

Raman Chirakal, Richard Adams, G. Firnau, Gary J. Schrobilgen, G. Coates, E.S. Garnett,

Lung Cancer Research Studies

Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [18O]O2. A method for the routine production of clinically useful quantities of [18F]F2 having a specific activity of 35 Ci/mmol has been developed and implemented using an 11 MeV proton cyclotron and [18O]O2. Based on the yield, purity, reproducibility, and specific activity of [18F]F2 this is the most efficient method reported thus far.