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Genetics of uterine leiomyomata

2000; Wiley; Volume: 28; Issue: 3 Linguagem: Inglês

10.1002/1098-2264(200007)28

1098-2264

Azra H. Ligon, Cynthia C. Morton,

Ovarian cancer diagnosis and treatment

Genes, Chromosomes and CancerVolume 28, Issue 3 p. 235-245 Review Article Genetics of uterine leiomyomata Azra H. Ligon, Azra H. Ligon Departments of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorCynthia C. Morton, Corresponding Author Cynthia C. Morton [email protected] Departments of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsDepartment of Pathology, Brigham and Women's Hospital, 75 Francis Street, Thorn 623, Boston, MA 02115Search for more papers by this author Azra H. Ligon, Azra H. Ligon Departments of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorCynthia C. Morton, Corresponding Author Cynthia C. Morton [email protected] Departments of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsDepartment of Pathology, Brigham and Women's Hospital, 75 Francis Street, Thorn 623, Boston, MA 02115Search for more papers by this author First published: 01 June 2000 https://doi.org/10.1002/1098-2264(200007)28:3 3.0.CO;2-7Citations: 86Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Leiomyomata represent the most common gynecologic tumors in women of reproductive age and are the primary indication for hysterectomy in the United States. Cytogenetic and genetic studies have in recent years advanced our understanding of the etiology of these tumors. Cytogenetic aberrations involving chromosomes 6, 7, 12, and 14 constitute the major chromosomal abnormalities seen in leiomyomata and have led to the discovery that disruptions or dysregulations of HMGIC and HMGIY contribute to the development of these tumors. Based on the finding of a variety of other consistent chromosomal aberrations detected in these tumors, other genes with fundamental roles in the pathobiology of uterine leiomyomata await identification. Genes Chromosomes Cancer 28:235–245, 2000. © 2000 Wiley-Liss, Inc. REFERENCES Abe N, Watanabe T, Sugiyama M, Uchimura H, Chiappetta G, Fusco A, Atomi Y. 1999. Determination of high mobility group I(Y) expression level in colorectal neoplasias: a potential diagnostic marker. Cancer Res 59: 1169–1174. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K. 1995. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82: 57–65. Ashar HR, Cherath L, Przybysz KM, Chada K. 1996. Genomic characterization of human HMGI-C, a member of the accessory transcription factor family found at translocation breakpoints in lipomas. Genomics 31: 207–214. Berlingieri MT, Manfioletti G, Santoro M. 1995. Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells. Mol Cell Biol 15: 1545–1553. Brosens I, Deprest J, Dal Cin P, Van den Berghe H. 1998. Clinical significance of cytogenetic abnormalities in uterine myomas. Fertil Steril 69: 232–235. Bullerdiek J, Bartnitzke S, Weinberg M, Chilla R, Haubrich J, Schloot W. 1987. Rearrangements of chromosome region 12q13-15 in pleomorphic adenomas of the human salivary gland (PSA). Cytogenet Cell Genet 45: 187–190. Calabrese G, Di Virgillio C, Cianchetti E, Franchi PG, Stuppia L, Parruti G, Bianchi PG, Palka G. 1991. Chromosome abnormalities in breast fibroadenomas. Genes Chromosomes Cancer 3: 202–204. Calogero S, Grassi F, Aguzzi A, Voigtlander T, Ferrier P, Ferrari S, Bianchi ME. 1999. The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat Genet 22: 276–280. Casartelli C, Ruzzene MAM, Rogatto SR, Philbert PMP. 1989. A cytogenetic study of uterine leiomyomas. Cancer Genet Cytogenet 41: 279. Cavenee WK, Scrable HJ, James CD. 1991. Molecular genetics of human cancer predisposition and progression. Mut Res 247: 199–202. Chiappetta G, Bandiera A, Berlingieri MT, Visconti R, Manfioletti G, Battista S, Martinez-Tello FJ, Santoro M, Giancotti V, Fusco A. 1995. The expression of the high mobility group HMGI(Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. Oncogene 10: 1307—1314. Chiappetta G, Avantaggiato V, Visconti R, Fedele M, Battista S, Trapasso F, Merciai BM, Fidanza V, Giancotti V, Santoro M, Simeone A, Fusco A. 1996. High level expression of the HMGI(Y) gene during embryonic development. Oncogene 13: 2439–2446. Chiappetta G, Tallini G, De Biasio MC, Manfioletti G, Martinez-Tello FJ, Pentimalli F, de Nigris F, Mastro A, Botti G, Fedele M, Berger N, Santoro M, Giancotti V, Fusco A. 1998. Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res 58: 4193–4198. Cotran RS, Kumar V, Robbins SL. 1989. Robbins Pathologic Basis of Disease. Philadelphia: W.B. Saunders Company. Cramer SF, Patel A. 1990. The frequency of uterine leiomyomas. Am J Clin Pathol 94: 435–438. Dal Cin P, Vanni R, Marras S, Moerman P, Kool P, Andria M, Valdes E, Deprest J, Van de Ven W, Van den Berghe H. 1995. Four cytogenetic subgroups can be identified in endometrial polyps. Cancer Res 55: 1565–1568. Dal Cin P, Van den Berghe H, Sciot R, de Wever I. 1997a. Deletion of the long arm of chromosome 7 in lipoma. Cancer Genet Cytogenet 96: 85–86. Dal Cin P, Wanschura S, Christiaens MR, Van den Berghe I, Moerman P, Polito P, Kazmierczak B, Bullerdiek J, Van den Berghe H. 1997b. Hamartoma of the breast with involvement of 6p21 and rearrangement of HMGI(Y). Cancer 20: 90–92. Davidovitz Y, Zimlichman R, Rosner E, Berkowic M, Ballin A, Meytes D. 1997. Deletion of the long arm of chromosome 7 in myelomonocytic leukemia with bone marrow eosinophilia. Cancer Genet Cytogenet 97: 122–124. Dong S-Y, Morgan R, Stone J, Meloni-Ehrig AM, Chen Z, Malawer MM, Sandberg AS. 1998. Translocation (12;14) in lipoma: a case report and review of the literature. Cancer Genet Cytogenet 103: 59–61. Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjold M, Gustafsson J-A. 1997. Human estrogen receptor B-gene structure, chromosomal localization, and expression pattern. J Clin Endocrin Metab 82: 4258–4265. Fan SX, Sreekantaiah C, Berger CS, Medchill M, Pedron S, Sandberg AA. 1990. Cytogenetic findings in nine leiomyomas of the uterus. Cancer Genet Cytogenet 47: 179–189. Fischer K, Frohling S, Scherer SW, Brown JM, Scholl C, Stingenbauer S, Tsui L-C, Lichter P, Dohner H. 1997. Molecular cytogenetic delineation of deletions and translocations involving chromosome band 7q22 in myeloid leukemias. Blood 89: 2036–2041. Fletcher JA, Longtine J, Wallace K, Mentzer SJ, Sugarbaker DJ. 1995. Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: evidence for a pathogenic relationship with lipomas and leiomyomas. Genes Chromosomes Cancer 12: 220–223. Friedmann M, Holth LT, Zoghbi HY, Reeves R. 1993. Organization, inducible expression and chomosome localization of the human HMGI(Y) nonhistone protein gene. Nucl Acids Res 21: 4259–4267. Fryns JP, Haspeslagh M, de Muelenaere A, Van Den Berghe H. 1985. 9p trisomy/18p distal monosomy and multiple cutaneous leiomyomata: another specific chromosomal site (18pter) in dominantly inherited multiple tumors. Hum Genet 70: 284–286. Garcia Muret MP, Pujol RM, Alomar A, Calaf J, de Moragas JM. 1988. Familial leiomyomatosis cutis et uteri (Reed's syndrome). Arch Dermat Res 280: S29–S32. Gattas GJF, Quade BJ, Nowak RA, Morton CC. 1999. HMGIC expression in human adult and fetal tissues and in uterine leiomyomata. Genes Chromosomes Cancer 25: 316–322. Giancotti V, Berlingieri MT, Di Fiore PP, Fusco A, Vecchio G, Crane-Robinson C. 1985. Changes in nuclear proteins on transformation of rat epithelial thyroid cells by a murine sarcoma retrovirus. Cancer Res 45: 6051–6057. Giancotti V, Pani B, D'Andrea P, Berlingieri MT, Di Fiore PP, Fusco A, Vecchio G, Philip R, Crane-Robinson C, Nicolas RH, et al. 1987. Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genes. EMBO J 6: 1981–1987. Giancotti V, Buratti E, Perissin L, Zorzet S, Balmain A, Portella G, Fusco A, Goodwin GH. 1989. Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different procedures. Exp Cell Res 184: 538–545. Goyette MC, Cho K, Fasching CL, Levy DB, Kinzler KW, Paraskeva C, Vogelstein B, Stanbridge EJ. 1992. Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol Cell Biol 12: 1387–1395. Hashimoto K, Azuma C, Kamiura S, Kimura T, Nobunaga T, Kanai T, Sawada M, Noguchi S, Saji F. 1995. Clonal determination of uterine leiomyomas by analyzing differential inactivation of the X-chromosome-linked phophoglycerokinase gene. Gynecol Obstet Invest 40: 204–208. Havel G, Wedell B, Dahlenfors R, Mark J. 1989. Cytogenetic relationship between uterine lipoleiomyomas and typical leiomyomas. Virchow Arch 57: 77–79. Hess JL. 1998. Chromosomal translocations in benign tumors: the HMGI proteins. Am J Clin Pathol 109: 251–261. Hirning-Folz U, Wilda M, Rippe V, Bullerdiek J, Hameister H. 1998. The expression pattern of the HMGIC gene during development. Genes Chromosomes Cancer 23: 350–357. Holt JT, Morton CC, Nienhuis AW, Leder P. 1987. Molecular mechanisms of hematological neoplasms, In G Stamatoyannopoulos, AW Nienhuis, P Leder, PW Majerus, editors. The molecular basis of blood diseases. Philadelphia: W.B. Saunders, p 360–362. Ishiai M, Dean FB, Okumura K, Abe M, Moon KY, Amin AA, Kagotani K, Taguchi H, Murakami Y, Hanaoka F, O'Donnell M, Hurwitz J, Eki T. 1997. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue ORC5L maps to 7q22. Genomics 46: 294–298. Ishwad CS, Ferrell RE, Davare J, Meloni AM, Sandberg AA, Surti U. 1995. Molecular and cytogenetic analysis of chromosome 7 in uterine leiomyomas. Genes Chromosomes Cancer 14: 51–55. Ishwad CS, Ferrell RE, Hanley K, Davare J, Meloni AM, Sandberg AA, Surti U. 1997. Two discrete regions of deletion at 7q in uterine leiomyomas. Genes Chromosomes Cancer 19: 156–160. Kazmierczak B, Wanschura S, Meyer-Bolte K, Caselitz J, Meister P, Bartnitzke S, Van de Ven W, Bullderdiek J. 1995a. Cytogenetic and molecular analysis of an aggressive angiomyxoma. Am J Pathol 147: 580–585. Kazmierczak B, Hennig Y, Wanschura S, Rogalla P, Bartnitzke S, Van de Ven W, Bullerdiek J. 1995b. Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. Cancer Res 55: 6038–6039. Kazmierczak B, Bol S, Wanschura S, Bartnitzke S, Bullerdiek J. 1996a. PAC clone containing the HMGI(Y) gene spans the breakpoint of a 6p21 translocation in a uterine leiomyoma cell line. Genes Chromosomes Cancer 17: 191–193. Kazmierczak B, Pohnke Y, Bullerdiek J. 1996b. Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations. Genomics 38: 223–226. Kiechle-Schwarz M, Sreekantaiah C, Berger CS, Pedron S, Medchill MT, Surti U, Sandberg AA. 1991. Nonrandom cytogenetic changes in leiomyomas of the female genitourinary tract. Cancer Genet Cytogenet 53: 125–136. Kim DH, Park YS, Park CJ, Son KC, Nam ES, Shin HS, Ryu JW, Kim DS, Park CK, Park YE. 1999. Expression of the HMGI(Y) gene in human colorectal cancer. Int J Cancer 84: 376–380. Kjerulff KH, Guzinski GM, Langenberg PW, Adler Moye NE, Kazandjian VA. 1993. Hysterectomy and race. Obstet Gynecol 82: 757–764. Lammie GA, Smith R, Silver J, Brookes S, Dickson C, Peters G. 1992. Proviral insertions near cyclin D1 in mouse lymphomas: a parallel for BCL1 translocations in human B-cell neoplasms. Oncogene 7: 2381–2387. Le Beau MM, Espinosa R III, Davis EM, Eisenbart JD, Larson RA, Green ED. 1996. Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases. Blood 88: 1930–1935. Liang H, Fairman J, Claxton DF, Nowell PC, Green ED, Nagarajan L. 1998. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci. Proc Natl Acad Sci USA 95: 3781–3785. Linder D, Gartler SM. 1965. Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas. Science 150: 67–69. Mandahl N, Orndal C, Heim S, Willen H, Rydholm A, Bauer HC, Mitelman F. 1993. Aberrations of chromosome segment 12q13–15 characterize a subgroup of hemangiopericytomas. Cancer 71: 3009–3013. Mark J, Havel G, Grepp C, Dahlenfors R, Wedell B. 1989. Cytogenetical observations in human benign uterine leiomyomas. Anticancer Res 8: 621–626. Mark J, Havel G, Grepp C, Dahlenfors R, Wedell LB. 1990. Chromosomal patterns in human benign uterine leiomyomas. Cancer Genet Cytogenet 44: 1–13. Mashal RD, Schoenberg Fejzo ML, Friedman AJ, Mitchner N, Nowak RA, Rein MS, Morton CC, Sklar J. 1994. Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata. Genes Chromosomes Cancer 11: 1–6. Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA, Willet WC, Hunter DJ. 1998. Variation of the incidence of uterine leiomyomata among premenopausal women by age and race. Obstet Gynecol 90: 967–973. Meilahn EN, Matthews KA, Egeland G, Kelsey SF. 1989. Characteristics of women with hysterectomy. Maturitas 11: 319–329. Meloni AM, Surti U, Contento AM, Davar J, Sandberg AA. 1992. Uterine leiomyomas: cytogenetic and histologic profile. Obstet Gynecol 80: 209–217. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, Poustka A. 1997. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours. Nat Genet 17: 32–39. Mosselman S, Polman J, Dijkema R. 1996. ER Beta: identification and characterization of a novel human estrogen receptor. FEBS Lett 392: 49–53. National Center for Health Statistics Hysterectomies in the United States. 1987. Vital and Health Statistics Series 13, 92nd ed. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control. Nilbert M. 1991. Uterine Leiomyoma Cytogenetics. PhD thesis. University of Lund, Sweden. Nilbert M, Heim S. 1990. Uterine leiomyoma cytogenetics. Genes Chromosomes Cancer 2: 3–13. Nilbert M, Strombeck B. 1992. Independent origin of uterine leiomyomas with karyotypically identical alterations. Gynecol Obstet Invest 33: 246–248. Nilbert M, Heim S, Mandahl N, Floderus U-M, Willen H, Akerman M, Mitelman F. 1988. Ring formation and structural rearrangements of chromosome 1 as secondary changes in uterine leiomyomas with t(12;14)(q14–15;q23–24). Cancer Genet Cytogenet 36: 183–190. Nilbert M, Heim S, Mandahl N, Floderus U-M, Willen H, Mitelman F. 1989. Different karyotypic abnormalities, t(1;6) and del(7), in two uterine leiomyomas from the same patient. Cancer Genet Cytogenet 42: 51–53. Nilbert M, Heim S, Mandahl N, Floderus U-M, Willen H, Mitelman F. 1990. Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), +12, and t(12;14), in 44 uterine leiomyomas. Hum Genet 85: 605–611. Osborne LR, Herbrick JA, Greavette T, Heng HH, Tsui LC, Scherer SW. 1997. PMS2-related genes flank rearrangement breakpoints associated with Williams syndrome and other diseases on human chromosome 7. Genomics 45: 402–406. Ozisik YY, Meloni AM, Surti U, Davare J, Sandberg AA. 1992. Inversion (X)(p22q13) in a uterine leiomyoma. Cancer Genet Cytogenet 61: 131–133. Ozisik YY, Meloni AM, Surti U, Sandberg AA. 1993a. Deletion 7q22 in uterine leiomyomata: a cytogenetic review. Cancer Genet Cytogenet 23: 305–313. Ozisik YY, Meloni AM, Powell M, Surti U, Sandberg AA. 1993b. Chromosome 7 biclonality in uterine leiomyoma. Cancer Genet Cytogenet 67: 59–64. Ozisik YY, Meloni AM, Stephenson CF, Peier A, Moore GE, Sandberg AA. 1994. Chromosome abnormalities in breast fibroadenomas. Cancer Genet Cytogenet 77: 125–128. Ozisik YY, Meloni AM, Altungoz O, Surti U, Sandberg AA. 1995. Translocation (6;10)(p21;q22) in uterine leiomyomas. Cancer Genet Cytogenet 79: 136–138. Pandis N, Heim S, Bardi G, Floderus U-M, Willen H, Mandahl N, Mitelman F. 1990. Parallel karyotypic evolution and tumor progression in uterine leiomyoma. Genes Chromosomes Cancer 2: 311–317. Pandis N, Heim S, Willen H, Bardi G, Floderus UM, Mandahl N, Mitelman F. 1991. Histologic-cytogenetic correlations in uterine leiomyomas. Int J Gynecol Cancer 1: 163–168. Pedeutour F, Quade B, Weremowicz S, Dal Cin P, Ali S, Morton CC. 1998. Localization and expression of the human estrogen receptor beta gene in uterine leiomyomata. Genes Chromosomes Cancer 23: 361–366. Ram TG, Reeves R, Hosick HL. 1993. Elevated HMGI(Y) gene expression is associated with progressive transformation of mouse mammary epithelial cells. Cancer Res 53: 2655–2660. Reed WB, Walker R, Horowitz R. 1973. Cutaneous leiomyomata with uterine leiomyomata. Acta Derm Venereol 53: 409–416. Rein MS, Friedman AJ, Barbieri RL, Pavelka K, Fletcher JA, Morton CC. 1991. Cytogenetic abnormalities in uterine leiomyomata. Obstet Gynecol 77: 923–926. Rein MS, Powell WL, Walters FC, Weremowicz S, Cantor RM, Barbieri RL, Morton CC. 1998. Cytogenetic abnormalities in uterine myomas are associated with myoma size. Mol Hum Reprod 4: 83–86. Rogalla P, Drechsler K, Frey G, Hennig Y, Helmke B, Bonk U, Bullerdiek J. 1996. HMGI-C expression patterns in human tissues: implications for the genesis of frequent mesenchymal tumors. Am J Pathol 149: 775–779. Sait SN, Dal Cin P, Ovanessoff S, Sandberg AA. 1989. A uterine leiomyoma showing both t(12;14) and del(7) abnormalities. Cancer Genet Cytogenet 37: 157–161. Sargent MS, Weremowicz S, Rein MS, Morton CC. 1994. Translocations in 7q22 define a critical region in uterine leiomyomata. Cancer Genet Cytogenet 77: 65–68. Schoenberg Fejzo M, Yoon S-J, Montgomery KT, Rein MS, Weremowicz S, Krauter KS, Dorman TE, Fletcher JA, Mao J-I, Moir DT, Kucherlapati RS, Morton CC. 1995. Identification of a YAC spanning the translocation breakpoints in uterine leiomyomata, pulmonary chondroid hamartoma, and lipoma: physical mapping of the 12q14-15 breakpoint region in uterine leiomyomata. Genomics 26: 265–271. Schoenberg Fejzo M, Ashar HR, Krauter KS, Powell WL, Rein MS, Weremowicz S, Yoon S-J, Kucherlapati RS, Chada K, Morton CC. 1996. Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. Genes Chromosomes Cancer 17: 1–6. Schoenmakers EF, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJ. 1995. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumors. Nat Genet 10: 436–444. Schoenmakers EF, Huysmans C, Van de Ven WJ. 1999. Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. Cancer Res 59: 19–23. Sornberger K, Weremowicz S, Pedeutour FB, Ligon AH, Quade BJ, Morton CC. 1999. Expression of HMGI(Y) in three uterine leiomyomata with complex rearrangements of chromosome 6. Cancer Genet Cytogenet 114: 9–16. Sreekantaiah C, Sandberg AA. 1991. Clustering of aberrations to specific chromosome regions in benign neoplasms. Int J Cancer 48: 194–198. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirstos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW. 1998. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95: 29–39. Steck PA, Pershouse MA, Jasser SA, Yung WKA, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DHF, Tavtigian SV. 1997. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356–362. Swerdlow SH, Zukerberg LR, Yang WI, Harris NL, Williams ME. 1996. The morphologic spectrum of non-Hodgkin's lymphomas with BCL1/cyclin D1 gene rearrangements. Am J Surg Pathol 20: 627–640. Tallini G, Dal Cin P. 1999. HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors. Adv Anat Pathol 6: 237–246. Tallini G, Dal Cin P, Rhoden KJ, Chiapetta G, Manfioletti G, Giancotti V, Fusco A, Van den Berghe H, Sciot R. 1997. Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: Immunohistochemical reactivity correlates with karyotypic alterations. Am J Pathol 151: 37–43. Tamimi Y, van der Poel HG, Denyn MM, Umbas R, Karthaus HF, Debruyne FM, Schalken JA. 1993. Increased expression of HMGI(Y) in high grade prostatic cancer determined by in situ hybridization. Cancer Res 53: 5512–5516. Thyresson HN, Su WPD. 1981. Familial cutaneous leiomyomatosis. Am Acad Dermatol 4: 430–434. Townsend DE, Sparkes RS, Baluda MC, McClelland G. 1970. Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis of glucose-6-phosphate dehydrogenase. Am J Obstet Gynecol 107: 1168–1174. Treloar SA, Martin NG, Dennerstein L, Raphael B, Heath AC. 1992. Pathways to hysterectomy: insights from longitudinal twin research. Am J Obstet Gynecol 167: 82–88. Tsui L-C, Donis-Keller H, Grzeschik K-H. 1995. Report of the second international workshop on human chromosome 7 mapping. 1994. Cytogenet Cell Genet 71: 1–13. Turc-Carel C, Dal Cin P, Rao U, Karakousis C, Sandberg AA. 1986. Cytogenetic studies of adipose tissue tumors. I. A benign lipoma with reciprocal translocation t(3;12)(q28;q14). Cancer Genet Cytogenet 23: 283–289. Turc-Carel C, Dal Cin P, Boghosian L, Terk-Zakarian J, Sandberg AA. 1988. Consistent breakpoints in region 14q22–q24 in uterine leiomyoma. Cancer Genet Cytogenet 32: 25–31. Vachon G, Cohen B, Pfeifle C, McGuffin ME, Botas J, Coheb SM. 1992. Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distalless. Cell 71: 437–450. van der Heijden O, Chiu H-C, Park T-C, Takahashi H, LiVolsi VA, Risinger JI, Barrett JC, Berchuck A, Evans AC, Behbakht K, Menzin AW, Liu PC, Benjamin I, Morgan MA, King SA, Rubin SC, Boyd J. 1998. Allelotype analysis of uterine leiomyoma: localization of a potential tumor suppressor gene to a 4-cM region of chromosome 7q. Mol Carcinogen 23: 243–247. Vanni R, Nieddu M, Paoli R, Lecca U. 1989. Uterine leiomyoma cytogenetics. I. Rearrangements of chromosome 12. Cancer Genet Cytogenet 37: 49–54. Vanni R, Lecca U, Faa G. 1991. Uterine leiomyoma cytogenetics. II. Report of forty cases. Cancer Genet Cytogenet 53: 247–256. Vanni R, Dal Cin P, Marras S, Moerman P, Andria M, Valdes E, Deprest J, Van den Berghe H. 1993. Endometrial polyp: another benign tumor characterized by 12q13–15 changes. Cancer Genet Cytogenet 68: 32–33. Vanni R, Marras S, Schoenmakers EFPM, Dal Cin P, Kazmierczak B, Senger G, Bullderdiek J, Van de Ven WJM, Van den Berghe H. 1997. Molecular cytogenetic characterization of del(7q) in two uterine leiomyoma-derived cell lines. Genes Chromosomes Cancer 18: 155–161. Vikhlyaeva EM, Khodzhaeva ZS, Fantschenko ND. 1995. Familial predisposition to uterine leiomyomas. Int J Gyn Obstet 51: 127–131. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ. 1999. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285: 248–251. Wanschura S, Dal Cin P, Kazmierczak B, Bartnitzke S, Van den Berghe H, Bullerdiek J. 1997. Hidden paracentric inversions of chromosome arm 12q affecting the HMGIC gene. Genes Chromosomes Cancer 18: 322–323. Weremowicz S, Morton C. 1999. Is HMGIC rearranged due to cryptic paracentric inversion of 12q in karyotypically normal uterine leiomyomas? Genes Chromosomes Cancer 24: 172–173. Williams AJ, Powell WL, Collins T, Morton CC. 1997. HMGI(Y) expression in human uterine leiomyoma: involvement of another high-mobility group architectural factor in a benign neoplasm. Am J Pathol 150: 911. Wolffe AP. 1999. Architectural regulations and HMG1. Nat Genet 22: 215–217. Wong IL, Nelson LM, Ward K. 1992. Uterine leiomyomata are clonal tumors as determined by an X chromosome methylation sensitive DNA polymorphism. 39th Annual Meeting of the Society for Gynecologic Investigation, San Antonio, TX. Xiao S, Lux M, Reeves R, Hudson T, Fletcher J. 1997. HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma. Am J Pathol 150: 901–910. Xing YP, Powell WL, Morton C. 1997. The del(7q) subgroup in uterine leiomyomata: genetic and biologic characteristics. Cancer Genet Cytogenet 98: 69–74. Yi J, Beckerle MC. 1998. The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. Genomics 49: 314–316. Zeng WR, Scherer SW, Koutsilieris M, Huizenga JJ, Filteau F, Tsui L-C, Nepveu A. 1997. Loss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas. Oncogene 14: 2355–2365. Zhou X, Benson KF, Ashar HR, Chada K. 1995. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 376: 771–774. Citing Literature Volume28, Issue3July 2000Pages 235-245 ReferencesRelatedInformation