An appraisal of new variants of Dde amine protecting group for solid phase peptide synthesis
1998; Elsevier BV; Volume: 39; Issue: 12 Linguagem: Inglês
10.1016/s0040-4039(97)10828-0
ISSN1873-3581
AutoresSiri Ram Chhabra, Bhupinder Hothi, David J. Evans, Peter D. White, Barrie W. Bycroft, Weng C. Chan,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoA series of new variants of Dde, substituted at the exocyclic alkene position have been developed and their application in solid phase peptide synthesis assessed. The new derivatives offer complete resistance towards 20% piperidine in DMF and provide a considerable barrier towards N→N′-intramolecular migration.
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