Molecular mechanisms of action of auranofin and other gold complexes as related to their biologic activities
1983; Elsevier BV; Volume: 75; Issue: 6 Linguagem: Inglês
10.1016/0002-9343(83)90482-5
ISSN1555-7162
AutoresStanley T. Crooke, Christopher K. Mirabelli,
Tópico(s)Pesticide Exposure and Toxicity
ResumoThe molecular mechanisms of action of gold complexes in the treatment of rheumatoid arthritis are partially known, as are the mechanisms of action and potential utility of gold complexes in the treatment of neoplastic disease. In this paper, data relative to the mechanism of cytotoxicity and structure activity relationships are presented. Concepts of future research are also discussed.
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