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Expression of a Retrovirus Encoding Human HPRT in Mice

1984; American Association for the Advancement of Science; Volume: 225; Issue: 4662 Linguagem: Inglês

10.1126/science.6377498

1095-9203

A. Dusty Miller, Robert J. Eckner, Douglas J. Jolly, Theodore Friedmann, Inder M. Verma,

Cytomegalovirus and herpesvirus research

Transmissible retroviruses encoding human hypoxanthine phosphoribosyltransferase (HPRT) were used to infect mouse bone marrow cells in vitro, and the infected cells were transplanted into mice. Both active human HPRT-protein and chronic HPRT-virus production were detected in hematopoietic tissue of the mice, showing transfer of the gene. These results indicate the possible use of retroviruses for somatic cell therapy.