Portal de Periódicos da CAPES

Association of HLA Class I and Class II Antigens with Rheumatic Fever in a Turkish Population

1993; Taylor & Francis; Volume: 22; Issue: 2 Linguagem: Inglês

10.3109/03009749309095114

1502-7732

Ümit Ölmez, Murat Turgay, Seren Özeni̇rler, Hüseyin Tutkak, Nurşen Düzgün, Murat Duman, G. Tokgöz,

Autoimmune and Inflammatory Disorders Research

Ölmez Ü, Turgay M, Özenirler S, Tutkak H, Düzgün N, Duman M, Tokgöz G. Association of HLA Class I and Class II Antigens with Rheumatic Fever in a Turkish Population. Scand J Rheumatol 22: 49–52.The distribution of class I and class II HLA antigens of 100 Turkish patients with rheumatic fever, 77 of whom had cardiac involvement, was examined. We compared the results with a control group of identical origin. The frequency of HLA A10 and HLA B35 antigens were found significantly higher in patients with rheumatic fever (p<0.05. p<0.01, respectively). The frequency of HLA A10 and HLA DRw11 in patients with cardiac involvement were significantly higher than in those without cardiac involvement (p<0.05, p<0.01, respectively). On the other hand, HLA Cw2 antigen frequency was found significantly higher in patients without cardiac involvement than in those with rheumatic heart disease (p<0.05). We support the concept that rheumatic fever is an immunological reaction to group A, beta hemolytic streptococci in individuals who have genetic prcedisposition.