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CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma

2013; Elsevier BV; Volume: 122; Issue: 20 Linguagem: Inglês

10.1182/blood-2013-04-493361

1528-0020

Monica Casucci, Benedetta Nicolis di Robilant, Laura Falcone, Barbara Camisa, Margherita Norelli, Pietro Genovese, Bernhard Gentner, Fabiana Gullotta, Maurilio Ponzoni, Massimo Bernardi, Magda Marcatti, Aurore Saudemont, Claudio Bordignon, Barbara Savoldo, Fabio Ciceri, Luigi Naldini, Gianpietro Dotti, Chiara Bonini, Attilio Bondanza,

T-cell and B-cell Immunology

Key Points T cells genetically targeted to the tumor-promoting antigen CD44v6 are effective against AML and MM. CD44v6-targeted T cells do not recognize hematopoietic stem cells and keratinocytes but cause reversible monocytopenia.