A new fluorogenic probe for solution and intra-cellular sensing of trivalent cations in model human cells
2014; Elsevier BV; Volume: 194; Linguagem: Inglês
10.1016/j.snb.2013.12.049
ISSN1873-3077
AutoresSoham Samanta, Sudeep Goswami, Aiyagari Ramesh, Gopal Das,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoA new imidazole functionalized anthracene based Schiff base (L) was synthesized and it's selective colorimetric as well as fluorescence responses to trivalent metal cations (Al3+, Fe3+ and Cr3+) over a variety of divalent and monovalent metal cations in 1:1 methanol–water mixed solvent and in live HeLa cells were demonstrated. These selective colorimetric and fluorescence responses were explained as a consequence of protonation of L, where the lower Ksp values of M3+ (Al3+, Fe3+ and Cr3+) facilitated the generation of H+ through hydrolysis. This fluorogenic behavior of the ligand L was further confirmed by theoretical calculations.
Referência(s)