The reaction of the hydroxyl radical with glutathione in neutral and alkaline aqueous solution.
1982; National Institutes of Health; Volume: 89; Issue: 2 Linguagem: Inglês
Autores
Lars E. Sjöberg, Trygve E. Eriksen, Láśzló Révész,
Tópico(s)Lanthanide and Transition Metal Complexes
ResumoSJOBERG, L., ERIKSEN, T. E., AND REVESZ, L. The Reaction of the Hydroxyl Radical with Glutathione in Neutral and Alkaline Aqueous Solution. Radiat. Res. 89, 255-263 (1982). The reaction of OH with glutathione (y-glu-cys-gly) in neutral and alkaline aqueous solutions has been studied by pulse radiolysis. In addition to the sulfur-centered GS.(GSSG-.) radical formed by electron transfer or hydrogen abstraction from GS- (GSH), at least one carbon-centered radical is formed with pH-dependent yield by hydrogen abstraction from the y carbon or the amino group on the 'y-glutamyl moiety. The latter radical is transformed in a first-order reaction most probably to a carbon-centered radical on the cysteine group. No evidence for the formation of carbon-centered radicals was found in comparable experiments with cysteine and 2-mercaptopropionylglycine.
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