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Association of 1,5-Anhydroglucitol and 2-h Postprandial Blood Glucose in Type 2 Diabetic Patients

2008; American Diabetes Association; Volume: 31; Issue: 8 Linguagem: Inglês

10.2337/dc08-0385

1935-5548

Christoph Stettler, Matthias Stahl, Sabin Allemann, Peter Diem, Kurt Schmidlin, Marcel Zwahlen, Walter Riesen, Ulrich Keller, Emanuel Christ,

Metabolism, Diabetes, and Cancer

To assess the association of 1,5-anhydroglucitol (1,5-AG) with 2-h postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.In 55 patients, we examined self-measured postprandial blood glucose values for correlations with 1,5-AG values over prespecified preceding time periods (3 days, 1 week, and weekly up to 12 weeks).The correlation coefficients for postprandial glucose values were -0.34 (P < 0.05) for 3 days, -0.38 (P < 0.001) for 1 week, and -0.40 (P < 0.001) for 2 weeks preceding the measurement of 1,5-AG. Correlations declined for time periods >2 weeks before measurement of 1,5-AG. The correlation was lower with fasting/preprandial plasma glucose levels. There was no time dependency for the correlation between A1C and fasting or postprandial glucose.1,5-AG best reflected the 2-h postprandial glucose values of the 2 previous weeks.