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Renal handling of urea in subjects with persistent azotemia and normal renal function

1987; Elsevier BV; Volume: 32; Issue: 5 Linguagem: Inglês

10.1038/ki.1987.266

1523-1755

Giuseppe Conte, Antonio Dal Canton, Maurizio Terribile, Bruno Cianciaruso, Giovanni Di Minno, M Pannain, Domenico Russo, Vittorio E. Andreucci,

Dialysis and Renal Disease Management

Renal handling of urea in subjects with persistent axotemia and normal renal function.Fourteen subjects with persistent azotemia and normal glomerular filtration rate were studied hy renal clearances and hormonal determinations to establish the nephron site of altered urea transport and the mechanism(s) responsible for their azotemia.During constant alimentary protein.urea nitrogen appearance was normal and urea clearance was much lower than in 10 age-matched control subjects (23,3:+: 2.1 mlhnin and49.6:+:2.6 mllmin per 1.73 m 2 • P < 0.(01).Inulin