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An experimental outer membrane vesicle vaccine from N. meningitidis serogroup B strains that induces serum bactericidal activity to multiple serogroups

2011; Elsevier BV; Volume: 29; Issue: 44 Linguagem: Inglês

10.1016/j.vaccine.2011.07.124

1873-2518

Valerian B. Pinto, Elizabeth Morán, Francisco Cruz, Xinming Wang, Arthur Fridman, Wendell D. Zollinger, Craig T. Przysiecki, Robert Burden,

Neonatal and Maternal Infections

A trivalent native outer membrane vesicle vaccine that has potential to provide broad based protection against Neisseria meningitidis serogroup B strains has been developed. Preliminary immunogenicity studies in mice showed that the vaccine was capable of inducing an effective broad based bactericidal antibody response against N. meningitidis serogroup B strains. These findings in mice have been repeated with a cGMP trivalent NOMV vaccine and extended to show that the bactericidal antibody response induced by the vaccine in mice is effective against strains belonging to serogroups C, Y, W135, X, and NadA-expressing serogroup A strains. Taken together these results suggest that this experimental vaccine may provide protection against both serogroup B and non-serogroup B N. meningitidis strains.