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PREVENTION OF RECURRENT ABORTION WITH LEUCOCYTE TRANSFUSIONS

1981; Elsevier BV; Volume: 318; Issue: 8237 Linguagem: Inglês

10.1016/s0140-6736(81)90413-x

1474-547X

Colin G. Taylor, W. Pagé Faulk,

Pregnancy and preeclampsia studies

Three women, each with a history of three spontaneous abortions, were typed for A, B, C, and DR histocompatibility (HLA) antigens and found to share antigens with their husbands. The women were repeatedly transfused throughout pregnancy with leucocyte-enriched plasma from at least sixteen different erythrocyte-compatible donors. The pregnancies were normal and each mother produced a healthy baby. The presence of trophoblast/lymphocyte cross-reactive (TLX) antigens, which stimulate the mother to mount a response with blastocyst protective factors and which prevent maternal rejection of the antigenically unique embryo, might explain these results.