Collagenous gastritis revealed by severe anemia in a child
1998; Elsevier BV; Volume: 29; Issue: 8 Linguagem: Inglês
10.1016/s0046-8177(98)90461-0
ISSN1532-8392
AutoresJean‐François Côté, G. Fromont Hankard, Christophe Fauré, Jean‐François Mougenot, Laurent Holvoet, Jean‐Pierre Cézard, Jean Navarro, Michel Peuchmaur,
Tópico(s)Genetic factors in colorectal cancer
ResumoCollagenous gastritis is a rare histopathological disorder of unknown origin, characterized by a subepithelial collagen deposit greater than 10 μm thick, associated with an inflammatory infiltrate of the gastric mucosa. This report describes a second pediatric case of collagenous gastritis, revealed by severe anemia caused by gastric bleeding, as was the first case. Unlike the adult cases of collagenous gastritis, lesions were limited to the stomach, and remained unchanged on six series of biopsies taken during a 30 month follow-up, despite treatment with omeprazole, sucralfate and corticosteroids. An immunohistochemical study showed signs of local immune activation on all biopsy specimens, including overexpression of HLA-DR by epithelial cells, increased numbers of CD3+ intraepithelial lymphocytes, and CD25+ cells in the lamina propria. Although the cause of the disease remains unclear, our findings suggest that the histopathological lesions of collagenous gastritis may result from a local immune process.
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