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Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats

2010; Taylor & Francis; Volume: 17; Issue: 2 Linguagem: Inglês

10.3109/10717540903508995

1521-0464

Giovana Radomille Tófoli, Cíntia Maria Saia Cereda, Daniele Ribeiro de Araújo, Eneida de Paula, Rui Barbosa Brito Júnior, José Pedrazzoli Júnior, Eduardo C. Meurer, Fábio Alessandro Proença Barros, Francisco Carlos Groppo, Maria Cristina Volpato, José Ranali,

Dental Anxiety and Anesthesia Techniques

The pharmacokinetics and the local toxicity of commercial and liposome-encapsulated mepivacaine formulations injected intra-orally in rats were studied. Animals were divided in groups (n = 4–6) and treated with 0.1 mL of the formulations: 2% mepivacaine with 1:100,000 epinephrine (MVC2%EPI), 3% mepivacaine (MVC3%), and 2% liposome-encapsulated mepivacaine (MVCLUV). The results showed that the 2% liposome-encapsulated mepivacaine reduced Cmax, prolonged AUC0–∞ and t1/2 compared with 3% plain and 2% vasoconstritor-associated mepivacaine, after intraoral injection. In addition, it was also observed that liposomal mepivacaine might protect the tissue against local inflammation evoked by plain or vasoconstrictors-associated mepivacaine, giving supporting evidence for its safety and possible clinical use in dentistry.