Binary decisions in neurogenesis
1986; Elsevier BV; Volume: 9; Linguagem: Inglês
10.1016/0166-2236(86)90122-0
ISSN1878-108X
AutoresWilliam A. Harris, Mick McKeown,
Tópico(s)Circadian rhythm and melatonin
ResumoThe developmental relationship between the nervous system and the epidermis is intimate. In nematodes1, annelids2, arthropods3, and vertebrates4, neural and epidermal elements arise from common lineages. In many cases, cells can be induced to switch from one fate to the other by genetic or environmental changes2,4–8. The close relationship between these two ectodermal derivatives in a variety of animals suggests that they share common genetic instructions, at least up to a certain critical phase in their progressive determination. Recent work on the embryology and molecular biology of neural determination in nematodes and insects has shed light on this remarkable neural—epidermal decision.
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