Lactic Acidosis Associated with Cerebellar Vermal Atrophy and Cardiomyopathy
1978; Thieme Medical Publishers (Germany); Volume: 9; Issue: 03 Linguagem: Inglês
10.1055/s-0028-1091488
ISSN1439-1899
AutoresV R Challa, William R. Markesbery, Robert Baumann, Jonathan Noonan,
Tópico(s)Cardiac Valve Diseases and Treatments
ResumoThe association of fluctuating neurological signs and congestive cardiomyopathy with chronic lactic acidosis is described in a 5œ year old boy who ultimately succumbed to congestive heart failure. The autopsy findings included severe atrophy of the anterior cerebellar vermis and a hypertrophied heart with left sided endocardial fibroelastosis. Skeletal and cardial muscle calcification was prominent and probably due to the effect of intracellular metabolic alterations associated with lactic acidosis. A review of the literature shows that the combination of cardiomyopathy, isolated atrophy of cerebellar vermis and muscle fiber calcification have not been reported in association with idiopathic lactic acidosis previously.
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