Polyethylene glycol monomethyl ether sulfate-based background electrolytes in capillary electrophoresis
1996; Elsevier BV; Volume: 744; Issue: 1-2 Linguagem: Inglês
10.1016/0021-9673(96)00350-0
ISSN1873-3778
AutoresRobert L. Williams, Gyula Vigh,
Tópico(s)Analytical Chemistry and Chromatography
ResumoAbstract A homologous series of (polyethylene glycol monomethyl ether) hydrogensulfates has been synthesized, characterized and used as the source of anionic co-ions in mobility-matching background electrolytes designed to eliminate the efficiency-degrading effects of electromigration dispersion. The mobilities of the new anionic co-ions vary in the 5·10 −5 to 45·10 −5 cm 2 /Vs range in 25 m M mobility-matching background electrolytes, prepared from ϵ-aminocaproic acid and the respective (polyethylene glycol monomethyl ether) hydrogensulfate. It is demonstrated experimentally that the electromigration dispersion-related peak broadening can be minimized and difficult electrophoretic separations can be realized without significant alteration of the separation selectivity when these (polyethylene glycol monomethyl ether) sulfate anions are used as co-ions in mobility-matching background electrolytes.
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