Synthesis of Highly Oxygenated Dinaphthyl Ethers via S N Ar Reactions Promoted by Barton's Base
2003; American Chemical Society; Volume: 5; Issue: 7 Linguagem: Inglês
10.1021/ol034286z
ISSN1523-7060
Autores Tópico(s)Asymmetric Synthesis and Catalysis
Resumo[reaction: see text] Electron-rich dinaphthyl ethers were synthesized by S(N)Ar reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.
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