BIOLOGICAL AGGRESSIVENESS OF HEREDITARY PROSTATE CANCER: LONG-TERM EVALUATION FOLLOWING RADICAL PROSTATECTOMY
1998; Lippincott Williams & Wilkins; Volume: 160; Issue: 3 Part 1 Linguagem: Inglês
10.1016/s0022-5347(01)62748-4
ISSN1527-3792
AutoresG. Steven Bova, Alan W. Partin, Sarah D. Isaacs, Bob S. Carter, Terri Beaty, William B. Isaacs, Patrick C. Walsh,
Tópico(s)Genetic factors in colorectal cancer
ResumoNo AccessJournal of UrologyClinical Urology: Original Articles1 Sep 1998BIOLOGICAL AGGRESSIVENESS OF HEREDITARY PROSTATE CANCER: LONG-TERM EVALUATION FOLLOWING RADICAL PROSTATECTOMY G. STEVEN BOVA, ALAN W. PARTIN, SARAH D. ISAACS, BOB S. CARTER, TERRI L. BEATY, WILLIAM B. ISAACS, and PATRICK C. WALSH G. STEVEN BOVAG. STEVEN BOVA , ALAN W. PARTINALAN W. PARTIN , SARAH D. ISAACSSARAH D. ISAACS , BOB S. CARTERBOB S. CARTER , TERRI L. BEATYTERRI L. BEATY , WILLIAM B. ISAACSWILLIAM B. ISAACS , and PATRICK C. WALSHPATRICK C. WALSH View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62748-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We answer the question of whether, following radical prostatectomy, prostate cancer in patients with a family history of prostate cancer relapses biochemically at the same rate as prostate cancer in appropriately matched patients with no family history. Materials and Methods: The study was performed in 2 parts. In both parts prostate specific antigen (PSA) progression was defined as a postoperative elevation in serum PSA greater than 0.2 ng./ml. Part 1 included 656 patients who underwent radical prostatectomy by the same surgeon. Men with a family history of prostate cancer in a father or brother (94) were compared to those with no history of prostate cancer in a father or brother (562). Part 2 comprised 52 men with a family history of prostate cancer consistent with hereditary prostate cancer (HPC). HPC is defined as a family with 3 generations affected, 3 first-degree relatives affected or 2 relatives affected before age 55 years. Each member of this HPC group was matched by postoperative Gleason score and postoperative pathological stage with a patient who also underwent radical prostatectomy in the same time frame by the same surgeon but who reported no family history of prostate cancer by telephone interview and questionnaire. Results: In part 1, 94 probands (14%) reported a history of prostate cancer in the father or in at least 1 brother. The remaining 562 probands (85%) reported no known history of prostate cancer in the father or brother(s). There was no statistically significant difference in the probability of maintaining an undetectable PSA between these 2 groups. In part 2, 45 of 52 pairs (87%) were matched identically for all matching criteria. Mean follow time for the sporadic and hereditary groups was 5.4 and 5.1 years, respectively. There was no statistically significant difference in the probability of maintaining an undetectable PSA between the 2 groups. Conclusions: Men with an affected father or brother, or those with a family history consistent with HPC have the same outcome following radical prostatectomy as men with no family history of the disease. Combined with our previous studies, these findings suggest that there is no biologically important difference between hereditary and sporadic prostate cancers. References 1 : Recherches clinico-statistiques et genetiques sur les neoplasies de la prostate. Acat Genet. Statis.1956; 6: 304. Google Scholar 2 : An investigation of familial aspects of carcinoma of the prostate. Cancer1960; 13: 739. Google Scholar 3 : Prostate carcinoma and multiple primary malignancies. Study of a family and 109 consecutive prostate cancer patients. Cancer1966; 19: 1891. 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Abstract, Google Scholar From the Departments of Urology and Pathology, and The James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBrath J, Grill S, Ankerst D, Thompson I, Gschwend J and Herkommer K (2018) No Detrimental Effect of a Positive Family History on Long-Term Outcomes Following Radical ProstatectomyJournal of Urology, VOL. 195, NO. 2, (343-348), Online publication date: 1-Feb-2016.Roemeling S, Roobol M, de Vries S, Gosselaar C, van der Kwast T and Schröder F (2018) Prevalence, Treatment Modalities and Prognosis of Familial Prostate Cancer in a Screened PopulationJournal of Urology, VOL. 175, NO. 4, (1332-1336), Online publication date: 1-Apr-2006.Siddiqui S, Sengupta S, Slezak J, Bergstralh E, Zincke H and Blute M (2018) Impact of Familial and Hereditary Prostate Cancer on Cancer Specific Survival After Radical Retropubic ProstatectomyJournal of Urology, VOL. 176, NO. 3, (1118-1121), Online publication date: 1-Sep-2006.Roehl K, Loeb S, Antenor J, Corbin N and Catalona W (2018) Characteristics of Patients With Familial Versus Sporadic Prostate CancerJournal of Urology, VOL. 176, NO. 6, (2438-2442), Online publication date: 1-Dec-2006.GONZALGO M and ISAACS W (2018) Molecular Pathways to Prostate CancerJournal of Urology, VOL. 170, NO. 6, (2444-2452), Online publication date: 1-Dec-2003.Bratt O (2018) Hereditary Prostate Cancer: Clinical AspectsJournal of Urology, VOL. 168, NO. 3, (906-913), Online publication date: 1-Sep-2002.BRATT O, DAMBER J, EMANUELSSON M and GRÖNBERG H (2018) Hereditary Prostate Cancer: Clinical Characteristics and SurvivalJournal of Urology, VOL. 167, NO. 6, (2423-2426), Online publication date: 1-Jun-2002.NARAIN V, TIGUERT R, BANERJEE M, GRIGNON D, WOOD D and POWELL I (2018) BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY IN BLACK AND WHITE AMERICAN MEN WITH A POSITIVE OR NEGATIVE FAMILY HISTORY OF PROSTATE CANCERJournal of Urology, VOL. 165, NO. 2, (474-477), Online publication date: 1-Feb-2001. Volume 160Issue 3 Part 1September 1998Page: 660-663 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information G. STEVEN BOVA More articles by this author ALAN W. PARTIN More articles by this author SARAH D. ISAACS More articles by this author BOB S. CARTER More articles by this author TERRI L. BEATY More articles by this author WILLIAM B. ISAACS More articles by this author PATRICK C. WALSH More articles by this author Expand All Advertisement PDF downloadLoading ...
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