Portal de Periódicos da CAPES

Neuroprotection by Ketamine: A Review of the Experimental and Clinical Evidence

2009; Elsevier BV; Volume: 24; Issue: 1 Linguagem: Inglês

10.1053/j.jvca.2009.05.008

1532-8422

Judith A. Hudetz, Paul S. Pagel,

Anesthesia and Sedative Agents

NEUROPROTECTION MAY BE DEFINED AS the “prevention or amelioration of neuronal damage evidenced by abnormalities in cerebral metabolism, histopathology or neurologic function occurring after a hypoxic or an ischemic event.”1 Thus, the prevention of cerebral ischemia and the recovery of neural tissue that already has sustained an ischemic insult represent essential goals of neuroprotection. Neuroprotection may occur as a consequence of reduced O2 demand, enhanced O2 delivery, or attenuation of pathologic processes that contribute to cellular injury or death.