Portal de Periódicos da CAPES

Clinical Diagnosis of Common Scalp Disorders

2005; Elsevier BV; Volume: 10; Issue: 3 Linguagem: Inglês

10.1111/j.1087-0024.2005.10103.x

1529-1774

Boni E. Elewski,

Dermatological diseases and infestations

Scalp skin is unique on the body due to the density of hair follicles and high rate of sebum production. These features make it susceptible to superficial mycotic conditions (dandruff, seborrheic dermatitis, and tinea capitis), parasitic infestation (pediculosis capitis), and inflammatory conditions (psoriasis). Because these scalp conditions share similar clinical manifestations of scaling, inflammation, hair loss, and pruritus, differential diagnosis is critically important. Diagnostic techniques and effective treatment strategies for each of the above conditions will be discussed. Scalp skin is unique on the body due to the density of hair follicles and high rate of sebum production. These features make it susceptible to superficial mycotic conditions (dandruff, seborrheic dermatitis, and tinea capitis), parasitic infestation (pediculosis capitis), and inflammatory conditions (psoriasis). Because these scalp conditions share similar clinical manifestations of scaling, inflammation, hair loss, and pruritus, differential diagnosis is critically important. Diagnostic techniques and effective treatment strategies for each of the above conditions will be discussed. The skin of the scalp has several unique features that aid in its critical role of protecting the head. First, the follicular density is much higher, creating a dark, warm and moist environment. This provides thermal insulation, but also creates an environment conducive to parasitic infestation. Second, in adults there is a high rate of sebum production, which along with desquamated skin cells can provide a food source for microorganisms. Finally, the scalp skin is subjected to brushing and contact with other styling implements that can cause friction injury and may introduce microorganisms. These unique features of the scalp make it susceptible to superficial mycotic conditions (dandruff, seborrheic dermatitis, and tinea capitis), parasitic infestation (pediculosis capitis) and inflammatory conditions (psoriasis). These disease processes of the scalp can have significant overlap in clinical symptomatology. Hyperkeratosis (scaling), pruritus, alopecia, and inflammatory signs (erythema, purulence) are common symptoms of scalp disorders. Scaling and pruritus are extremely common complaints. In a survey of 735 adults in the United States, 39% reported having experienced some flaking, and almost 50% complained of scalp itch (data on file at Procter & Gamble). Therefore, a clear understanding of each disease process and its unique clinical manifestations is key to developing an accurate differential diagnosis. Seborrheic dermatitis and dandruff are now known to be two ends of a single disease spectrum caused by Malassezia species (Gemmer et al., 2002Gemmer C. DeAngelis Y. Theelen B. et al.Fast, noninvasive method for molecular detection and differentiation of Malassezia yeast species on human skin and application of the method to dandruff microbiology.J Clin Microbiol. 2002; 40: 3350-3357Crossref PubMed Scopus (178) Google Scholar;Erchiga and Florencio, 2002Erchiga V. Florencio V. Malassezia species in skin diseases.Curr Opin Infect Dis. 2002; 15: 133-142Crossref PubMed Scopus (117) Google Scholar). Dandruff is extremely common, affecting close to 50% of the world's population (Cardin, 1998Cardin C. Isolated dandruff.in: Baran R. Maibach H. Textbook of Cosmetic Dermatology. Malden, MA, Blackwell Science1998: 193-200Google Scholar). Because the Malassezias feed off of lipids, they are found most commonly in patients with high levels of sebaceous secretions and occur in locations where post-pubertal sebaceous gland activity is highest. Dandruff is therefore most prevalent between ages 15 and 50. Like dandruff, seborrheic dermatitis is rare between infancy and puberty because of immaturity of sebaceous glands; however, it often persists well past age 50 (Sinclair et al., 1999bSinclair R. Banfield C. Dawber R. Inflammatory dermatoses of the scalp.Handbook of Diseases of the Hair and Scalp. Malden, MA, Blackwell Science1999: 201-208Google Scholar). It is a chronic, recurrent condition, and patients generally experience frequent relapses. Dandruff is characterized by fine, loosely adherent, white or gray flakes that occur either diffusely or in localized patches on the hair-bearing portions of the scalp. Approximately 49% of patients with dandruff experience this flaking. Patients with dandruff also frequently experience pruritus (66%), irritation (25%), and a tight or dry feeling scalp (59%) (data on file at Procter & Gamble). Seborrheic dermatitis is characterized by inflammatory changes (erythema) covered by larger, yellow, greasy scales that accumulate to form crusts Figure 1. Patients with seborrheic dermatitis may experience mild pruritus as well. Seborrheic dermatitis is often not confined to the scalp, but occurs in other areas such as the face (particularly in the nasolabial folds, eyelid margins (blepharitis) and eyebrows), inside and behind the ears, the axilla, groin, and anterior chest. It occurs with increased frequency in immunocompromised patients, especially those with AIDS (Farthing et al., 1985Farthing C. Staughton R. Rowland Payne C. Skin disease in homosexual patients with Acquired Immune Deficiency Syndrome (AIDS) and lesser forms of human T cell Leukaemia Virus (HTLV III) disease.Clin Exp Dermatol. 1985; 10: 3-12Crossref PubMed Scopus (99) Google Scholar), and in patients with neurologic disorders such as Parkinson's disease and stroke. The mainstay of treatment of both dandruff and seborrheic dermatitis is anti-fungal shampoos that have minimum inhibitory concentrations against Malassezia (pyrithione zinc, ciclopirox, selenium sulfide, ketoconazole). Some patients may benefit from a keratolytic (salicylic acid) or an anti-proliferative (coal tar) shampoo. Finally, corticosteroids are generally effective at treating severe seborrheic dermatitis. Tinea capitis (ringworm of the scalp) is a dermatophytosis of the scalp hair follicle. It is primarily a disease of pre-pubescent children (Herbert, 1988Herbert A. Tinea capitis.Arch Dermatol. 1988; 124: 1554-1557Crossref PubMed Google Scholar). It has, however, recently been described in post-menopausal women Figure 2, perhaps because of the protective effect of sebaceous secretions during earlier adult life (Martin and Elewski, 2003Martin E. Elewski B. Tinea capitis in adult women masquerading as bacterial pyoderma.J Am Acad Dermatol. 2003; 49: S177-S179Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar). Dermatophytes can be grouped according to habitat—anthropophilic (human), zoophilic (animal), or geophilic (soil). Since most of these can infect hair, tinea capitis can be spread by contact with infected people, animals, or soil. It can, however, also be spread by sharing pillows, brushes, and clothing. There are three genera of dermatophytes: Microsporum, Trichophyton, and Epidermophyton. Both Microsporum and Trichophyton can invade the hair follicle. The species, however, involved tend to vary by time and region. T. tonsurans is found primarily in North America and Western Europe. In recent years there has been an increased incidence of T. tonsurans infection in urban areas of the United States (Elewski, 2000Elewski B. Tinea capitis: A current perspective.J Am Acad Dermatol. 2000; 42: 1-20Abstract Full Text Full Text PDF PubMed Google Scholar). This particular fungus is anthropophilic, and often is associated with socioeconomic status and overcrowding (Babel and Baughman, 1989Babel D. Baughman S. Evaluation of the adult carrier state in juvenile tinea capitis.J Am Acad Dermatol. 1989; 21: 1209-1212Abstract Full Text PDF PubMed Scopus (101) Google Scholar). Children of African and Hispanic descent are also more likely to exhibit T. tonsurans (Elewski, 2000Elewski B. Tinea capitis: A current perspective.J Am Acad Dermatol. 2000; 42: 1-20Abstract Full Text Full Text PDF PubMed Google Scholar). At this time, M. canis is a global problem. It is a zoophilic fungus, and may be passed from pets (especially cats) or other animals to children. There are two varieties of tinea capitis infection: inflammatory and non-inflammatory. The inflammatory variety can range from a few pustules in the scalp to widespread abscesses. Occasionally a kerion, which is a boggy, purulent, painful mass, may develop. Alopecia and tender cervical and post-auricular lymphadenopathy are often associated with the inflammatory process. The non-inflammatory variety usually presents with round or oval patches of alopecia. Fine scaling is often present, as well as prominent cervical and post-auricular adenopathy. The appearance of the alopecia differs depending on the type of hair invasion. Ectothrix infection is defined by fragmenting of hyphae into spores outside the hair shaft. This can lead to cuticle destruction and hair breakage a few millimeters from the scalp. Endothrix infection is characterized by hyphae that form spores within the hair cortex. These severely damaged hairs tend to break off at the surface of the scalp, leaving the patient with a characteristic "black dot" appearance of the affected scalp. T. tonsurans produces an endothrix infection that is usually associated with minimal scaling or inflammation. The presence of scalp fluorescence varies with the infecting dermatophyte. T. tonsurans and other endothrix infections do not fluoresce. M. canis and some other ectothrix infections do fluoresce. Therefore, Wood's light examination does not confirm or rule out the diagnosis of tinea capitis. Direct microscopy of skin scrapings (KOH) and fungal culture of hairs can both confirm dermatophytic infection. The current treatment of choice in the United States for all tinea of the scalp is griseofulvin (Sinclair et al., 1999aSinclair R. Banfield C. Dawber R. Infections and infestations of the hair.Handbook of Diseases of the Hair and Scalp. Malden, MA, Blackwell Science1999: 191-200Google Scholar). Alternatives are itraconazole, fluconazole, or terbinafine. Tinea capitis is generally treated until the patient is culture negative and the hair is regrowing, and with griseofulvin, the duration of therapy is generally 8 wk or more (Elewski, 2000Elewski B. Tinea capitis: A current perspective.J Am Acad Dermatol. 2000; 42: 1-20Abstract Full Text Full Text PDF PubMed Google Scholar). The patient and family members should be treated with anti-fungal shampoo to prevent re-infection. The source of exposure should also be identified. If it is a pet, the animal should be treated with an oral anti-fungal agent as well. Pediculosis capitis is caused by infestation with Pediculosis humanus capitis, or the head louse. It occurs most commonly in school-aged children, and its prevalence has been rising (Chosidow, 2000Chosidow O. Scabies and pediculosis.Lancet. 2000; 355: 819-826Abstract Full Text Full Text PDF PubMed Scopus (361) Google Scholar). Head lice are much more common in white than in black children in North America, apparently because the lice do not grab tightly to curled hair as well (Sinclair et al, 2000a, b). They are transmitted most efficiently by head to head contact, but can also be passed by sharing clothing, headgear, pillows, or combs and brushes. Head lice are usually confined to the scalp, especially the occipital and post-auricular regions. The adult lice measure 3–4 mm and can be seen with the naked eye. Nits (eggs) are firmly attached to the hair shaft close to the scalp. They may also be seen with the naked eye, but can be identified more easily using examination with a Wood's light. Symptoms develop a few weeks after the initial infestation. Pruritus is the cardinal symptom, and can be severe. Scratching may cause exudates and crusting. Prolonged infestation may lead to secondary bacterial infection, which can be accompanied by occipital lymphadenopathy and fever. Treatment of head lice is topical (shampoos, lotions, creams). There are several effective topical insecticides including malathion, carboryl, and permethrin. These are applied once, and then repeated again in 7–10 d to kill any remaining nits. These drugs are generally rotated every 3 y to decrease resistance. There are multiresistant head lice emerging, however, in which case oral treatment with cotrimoxazole or ivermectin can be used (Sinclair et al., 1999aSinclair R. Banfield C. Dawber R. Infections and infestations of the hair.Handbook of Diseases of the Hair and Scalp. Malden, MA, Blackwell Science1999: 191-200Google Scholar,Sinclair et al., 1999bSinclair R. Banfield C. Dawber R. Inflammatory dermatoses of the scalp.Handbook of Diseases of the Hair and Scalp. Malden, MA, Blackwell Science1999: 201-208Google Scholar). After topical treatment, nits need to be removed physically using a fine-toothed comb. This can be time consuming and painful, and pre-treatment with a conditioner is helpful. All clothes and bed linens should be washed in hot water and tumble dried on the hot cycle. Family members should be treated as well to prevent re-infestation. Psoriasis is a chronic, relapsing inflammatory disease that occurs in approximately 2% of the population; 50% of those affected will have scalp involvement (Sinclair et al., 1999bSinclair R. Banfield C. Dawber R. Inflammatory dermatoses of the scalp.Handbook of Diseases of the Hair and Scalp. Malden, MA, Blackwell Science1999: 201-208Google Scholar). The scalp is a prime area for psoriasis because of the incidence of friction injury/trauma and the lack of UV exposure. In some cases, the scalp is the only involved area. There is a genetic predisposition to psoriasis and family history is therefore important. Psoriasis is characterized by discrete erythematous plaques covered by a silver-gray scale. These plaques may be seen at the hair margins as well as on hair-bearing areas. Pruritis may be present, but is usually not severe. Early on, the plaques may appear similar to dandruff, and with disease progression, scalp lesions may be similar to those found in seborrheic dermatitis. Extensive hair loss may occur in severe erythrodermic and pustular psoriasis. Nail lesions such as pitting or onycholysis are frequent in patients with psoriasis. Scalp psoriasis can be very difficult to treat. Most mild cases of scalp psoriasis are treated with tar shampoo. Salicylic acid may be used as well to break down scales; topical corticosteroids may also be effective. Severe cases, or those associated with significant hair loss, may require systemic anti-psoriatic therapy such as methotrexate or cyclosporine. Although the differential diagnosis of itchy, scaly scalp is extensive, the primary causes are dandruff/seborrheic dermatitis, psoriasis, pediculosis capitis, and tinea capitis. The individual features of each are summarized in Table I. Developing an accurate differential diagnosis based on these unique clinical manifestations is critically important so that proper treatment can be instituted.Table IComparison of clinical characteristics of common scalp disordersMycoticDandruffSeborrheic dermatitisTinea capitisParasitic Pediculosis capitisInflammatory PsoriasisAgeAfter pubertyInfancy (cradle cap)Children, occasionally adults (more common post-menopausal women)School age childrenAnyAfter pubertyFluorescence (Wood's lamp)N/AN/A (not available)Occasionally (M. canis, M. adouinii, M. distortum, M. ferrugineum all fluoresce)Yes (nits)NoPruritusVariesMildOccasionallySevereMildScalingFineLarge, greasyVariableNo (nits may resemble scales)Well-demarcatedWhite or grayYellow(Mild to dense)Silver-grayInflammationNoYesMay occurOnly with superinfectionYesAlopeciaNoNoYesNoOccasionallyAdenopathyNoNoCervical and post-auricularOnly with superinfection Usually occipitalGenerally noHistoryHair washing habitsRecurrenceExposure to infected individuals and animalsExposureFamily history Recalcitrant to treatmentOtherResponds well to over-the-counter shampooPost-auricular region Immunocompromise Neurologic diseaseAffects all races, more common in children of African and Hispanic descentMore common in CaucasiansNail pitting/onycholysis Non-scalp lesions Rare on face Open table in a new tab