MOLECULAR AND CELLULAR PATHOGENESIS OF BENIGN PROSTATIC HYPERPLASIA
2004; Lippincott Williams & Wilkins; Volume: 172; Issue: 5 Linguagem: Inglês
10.1097/01.ju.0000133655.71782.14
ISSN1527-3792
Autores Tópico(s)Hormonal and reproductive studies
ResumoNo AccessJournal of UrologyReview Articles1 Nov 2004MOLECULAR AND CELLULAR PATHOGENESIS OF BENIGN PROSTATIC HYPERPLASIA KEITH L. LEE and DONNA M. PEEHL KEITH L. LEEKEITH L. LEE and DONNA M. PEEHLDONNA M. PEEHL View All Author Informationhttps://doi.org/10.1097/01.ju.0000133655.71782.14AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Symptomatic benign prostatic hyperplasia (BPH) is one of the most common ailments seen by the urologist. Significant advances have occurred in medical and surgical therapy, and in the understanding of the biology of this disease. However, the basic science literature is often conflicting and confusing, without a unified voice. We report the current state of knowledge of the molecular and cellular basis of BPH. Materials and Methods: We compiled and interpreted basic science studies relevant to BPH pathogenesis. Results: Cellular alterations that include changes in proliferation, differentiation, apoptosis and senescence in the epithelium and stroma are implicated in BPH pathogenesis. Molecular analyses have yielded numerous candidate genes important in disease progression. Differential expression of cytokines and growth factors in BPH tissue suggests roles for inflammation and hypoxia. Through the use of cell culture models the complex regulatory mechanisms of growth control in BPH are becoming defined. Conclusions: The scientific endeavor has resulted in great strides in our understanding of BPH on a molecular and cellular level. It is hopeful that basic science and translational research will improve treatment and prevention strategies for this common disease of elderly men. References 1 : The natural history of benign prostatic hyperplasia: what have we learned in the last decade?. Urology2000; 56: 3. Google Scholar 2 : Pathology of benign prostatic hyperplasia. Insight into etiology. 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Volume 172Issue 5November 2004Page: 1784-1791 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordsprostateprostatic hyperplasiaMetricsAuthor Information KEITH L. LEE More articles by this author DONNA M. PEEHL Financial interest and/or other relationship with Jenapharm GmbH More articles by this author Expand All Advertisement PDF downloadLoading ...
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