FATAL PRIMARY INFECTION DUE TO HUMAN HERPESVIRUS 6 VARIANT A IN A RENAL TRANSPLANT RECIPIENT
2001; Wolters Kluwer; Volume: 71; Issue: 2 Linguagem: Inglês
10.1097/00007890-200101270-00021
ISSN1534-6080
AutoresCamélia Rossi, Marie‐Luce Delforge, Fredrique Jacobs, Martin Wissing, Olivier Pradier, Myriam Remmelink, B. Byl, J.P. Thys, Corinne Liesnard,
Tópico(s)Polyomavirus and related diseases
ResumoWe describe a fatal primary human herpesvirus 6 (HHV-6) variant A infection in a kidney transplanted adult woman. On day 20 post transplantation (TX), after rejection therapy, the patient presented an acute hemophagocytic syndrome with hepatitis and central nervous system involvement. HHV-6 IgG and IgM antibodies seroconversion was demonstrated. HHV-6 variant A was the sole pathogen detected by nested PCR and/or culture in blood, bone marrow aspiration, liver biopsy, cerebrospinal fluid and bronchoalveolar lavage. The graft was HHV-6 seropositive and the patient was not transfused before day 28 post TX, suggesting that the virus was transmitted by the graft. Despite immunoglobulins, ganciclovir and foscarnet therapy, the HHV-6 infection progressed and led to severe aplasia. The patient developed Aspergillus fumigatus pneumonia and died from fulminant candidemia. This case demonstrated for the first time that HHV-6 variant A primary infection can cause life-threatening disseminated infection in immunosuppressed patients.
Referência(s)