The role of 5-HT1A serotonin and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats
1994; Elsevier BV; Volume: 177; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(94)90030-2
ISSN1872-7972
AutoresN. N. Bogdanov, M. B. Bogdanov,
Tópico(s)Receptor Mechanisms and Signaling
ResumoThe effects of buspirone (5 and 10 mg/kg i.p.), 8-OH-DPAT (0.25 mg/kg) and raclopride (2.5 mg/kg) on the EEG power spectra of the sensorimotor cortex were studied in freely moving rats. Buspirone (5 mg/kg) and 8-OH-DPAT produced selective slowing of the theta-activity. Buspirone (10 mg/kg) produced slowing of the theta-activity and increased the power of the alpha-band (9–11 Hz). Raclopride alone did not influence EEG power spectra. Simultaneous injection of 8-OH-DPAT and raclopride produced marked slowing of the theta-activity and increased the power of the alpha-band. The role of 5 HT1A and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats was discussed.
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