Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV
2012; Elsevier BV; Volume: 121; Issue: 9 Linguagem: Inglês
10.1182/blood-2012-07-447250
ISSN1528-0020
AutoresPablo Tebas, David Stein, Gwendolyn Binder-Scholl, Rithun Mukherjee, Troy Brady, Tessio Rebello, Laurent Humeau, Michael Kalos, Emmanouil Papasavvas, Luis J. Montaner, Daniel S. Schullery, Farida Shaheen, Andrea Brennan, Zhaohui Zheng, Julio Cotte, Vladimir Slepushkin, Elizabeth Veloso, Adonna Mackley, Wei‐Ting Hwang, Faten Aberra, Jenny Zhan, Jean Boyer, Ronald G. Collman, Frederic D. Bushman, Bruce L. Levine, Carl H. June,
Tópico(s)CAR-T cell therapy research
ResumoKey Points Adoptive transfer of autologous lentiviral-engineered T cells expressing an antisense is safe in chronic HIV infection. Conditionally replicating lentiviral vector was associated with antiviral effects in patients as assessed by viral evolution and viral load.
Referência(s)