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BIBTEX RIS

Plasma Advanced Glycation End Products (AGEs), Receptors for AGEs and Their Correlation with Inflammatory Markers in Middle School-Age Children

2013; Karger Publishers; Volume: 80; Issue: 5 Linguagem: Inglês

10.1159/000354831

ISSN

1663-2826

Autores

Siham Accacha, Warren Rosenfeld, A. Jacobson, Lesly Michel, F.J. Schnurr, Steven P. Shelov, Svetlana Ten, Claudia Boucher‐Berry, D E Carey, Phyllis Speiser, Barbara Lowell, Rushika Conroy, M. Klein, Ilene Fennoy, Robert Rapaport, Michael Rosenbaum,

Tópico(s)

Diabetes Management and Research

Resumo

<b><i>Aim:</i></b> Advanced glycation end products (AGEs) and/or their receptors (RAGE) are significantly positively correlated with adiposity, inflammation, dyslipidemia, and insulin resistance in adults. However, the relationships between AGEs, RAGE, and adiposity-related comorbidites in children have not been well studied. <b><i>Methods:</i></b> In a cross-sectional study of 88 children (age 11-15 years) from the New York area enrolled in the Reduce Obesity and Diabetes (ROAD) study, we examined the correlation of the AGE N<sup>ε</sup>-(carboxymethyl)lysine (CML), soluble RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) with adiposity, inflammatory markers [interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-α], adiponectin, lipids, insulin sensitivity, and insulin secretory capacity. <b><i>Results:</i></b> Pediatric CML levels were ∼20% below average adult levels. CML was significantly (p < 0.05) positively correlated with age and insulin sensitivity and negatively with adiposity, dyslipidemia and IL-6. sRAGE correlated positively with esRAGE and negatively with adiposity and IL-6. Both sRAGE and esRAGE correlated negatively with insulin secretory capacity. <b><i>Conclusion:</i></b> Our findings suggest that unlike adults, CML is negatively associated with adiposity and adiposity-related comorbidity risk in children. As in adults, sRAGE and esRAGE were, to varying degrees, negatively correlated with body fatness and risk factors for adiposity-related comorbidities.

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