Pirenzepine versus Cimetidine in Duodenal Ulcer
1982; Karger Publishers; Volume: 23; Issue: 2 Linguagem: Inglês
10.1159/000198696
ISSN1421-9867
AutoresBianchi Porro, P.R. Dal Monte, Marco Petrillo, G Giuliani Piccari, N. D’Imperio, S. Daniotti,
Tópico(s)Helicobacter pylori-related gastroenterology studies
Resumo90 patients with active duodenal ulcer were admitted to a double-blind trial to compare the effects of pirenzepine (150 mg/daily), cimetidine (1 g/daily) and placebo on the healing of duodenal ulcer. 5 patients did not complete the trial. In 21 of 29 patients (72%) receiving pirenzepine and in 21 of 28 (75%) of those receiving cimetidine, the ulcers had healed after 4 weeks of treatment compared with 10 of 28 (36%) patients receiving placebo (p < 0.01). Symptomatic improvement and reduction of antacid consumption were significantly more marked in the pirenzepine- and cimetidine-treated groups than in the placebo group. Tolerability of drugs was good. The results show that pirenzepine is as effective as cimetidine for the treatment of duodenal ulcer.
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