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Substitución asimétrica entre metanfetamina y anfetamina: Estudio de discriminación de drogas

2011; National Autonomous University of Mexico; Volume: 37; Issue: 1 Linguagem: Inglês

10.5514/rmac.v37.i1.24685

2007-0802

Florencio Miranda, Benita Cedillo-Ildefonso, Juan Carlos Jiménez, Gloria Núñez, Sergio Raúl Rodríguez,

Biochemical Analysis and Sensing Techniques

Methamphetamine (METH) is a form of amphetamine (AMPH) that is structurally and functionally similar. However METH differs from AMPH in that, at comparable doses, much higher levels of METH get into the brain, making it a more potent psychostimulant than AMPH. Despite of this, it has been reported that both METH and AMPH produce similar behavioral effects. Drug discrimination procedures are behavioral tools used to assess if two drugs produce similar or different behavioral effects. In the present study we evaluated the ability of various doses of AMPH to substitute for equivalent doses of METH in rats trained to discriminate METH from saline using a conditioned taste aversion as the drug discriminating procedure. After rats learned the discrimination METH-saline, various doses of METH or AMPH were evaluated on substitution tests. The results showed that different doses of METH produced a dose-dependent substitution. However, different doses of AMPH produced a partial dose-dependent substitution using equivalent doses of METH. These results suggest that METH produces higher behavioral effects than AMPH on a drug discrimination procedure.