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Establishment and characterization of a canine T-lymphoblastoid cell line derived from malignant lymphoma

1997; Elsevier BV; Volume: 59; Issue: 1-2 Linguagem: Inglês

10.1016/s0165-2427(97)00053-6

1873-2534

Yasuyuki Momoi, Yoshiko Okai, Toshihiro WATARI, Ryo Goitsuka, Hajime Tsujimoto, Atsuhiko Hasegawa,

T-cell and B-cell Immunology

A canine lymphoma cell line (CL-1) was established in culture from tumor cells found in the pleural fluid of a 7-year old female Japanese terrier with thymic form lymphoma. The CL-1 cells were positive for CD45 and MHC class II and negative for CD4, CD5, CD8, Thy-1 and B-cell specific antigen and surface immunoglobulin. The CL-1 cells had a rearranged T-cell receptor β-chain gene and a germ-line form immunoglobulin gene, indicating that the CL-1 cells represented a monoclonally expanded population of canine αβ T-cell lineage.