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Foxp3+ regulatory T cells in antiretroviral-naive HIV patients

2006; Lippincott Williams & Wilkins; Volume: 20; Issue: 12 Linguagem: Inglês

10.1097/01.aids.0000238415.98194.38

1473-5571

Martín Montes, Dorothy E. Lewis, César Sánchez, Diego López de Castilla, Edward A. Graviss, Carlos Seas, Eduardo Gotuzzo, A. Clinton White,

Immunodeficiency and Autoimmune Disorders

We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/microl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.