A Time to Kill: Targeting Apoptosis in Cancer
2015; Multidisciplinary Digital Publishing Institute; Volume: 16; Issue: 2 Linguagem: Inglês
10.3390/ijms16022942
ISSN1661-6596
AutoresJean L. Koff, Sampath Ramachandiran, Leon Bernal‐Mizrachi,
Tópico(s)Cancer-related Molecular Pathways
ResumoThe process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.
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