Skin Procollagen Peptidase in Normal and Pathologic Conditions
1974; Elsevier BV; Volume: 62; Issue: 6 Linguagem: Inglês
10.1111/1523-1747.ep12679431
ISSN1523-1747
AutoresCharles M. Lapière, Gérald Pierard,
Tópico(s)Skin Protection and Aging
ResumoProcollagen peptidase is a specific endopeptidase which excises the polypeptide extensions of procollagen to convert it into collagen. Its activity is required for the formation of stress-resistant collagen fibers. Enzymatic activity has been measured in extracts of animal and human skin. Procollagen peptidase is produced by fibroblasts; it is present in the extracellular space and an active form is not stored inside of the cells. Procollagen peptidase activity varies with the rate of collagen accretion in skin and it is increased in wound healing. Activity is elevated in pathologic skin conditions in which an increased synthetic activity of the fibroblasts would be expected.
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