Total synthesis of (±)−jolkinolide A, B, and E utilizing a new mild esterification followsd by intramolecular Wittig-Horner reaction
1989; Elsevier BV; Volume: 45; Issue: 5 Linguagem: Inglês
10.1016/0040-4020(89)80132-2
ISSN1464-5416
AutoresShigeo Katsumura, Akihiko Kimura, Sachihiko Isoe,
Tópico(s)Biological Activity of Diterpenoids and Biflavonoids
ResumoJolkinolide A, B, and E were efficiently synthesized from 9-methoxy-carbonyl-4,4,10-trimethyl-Δ6-8-octalone 8 through Δ8(14)-podocalpen-13-one 12. A new synthetic method of γ-ylidenbutenolide consisting of mild esterification and the succeeding intramolecular Wittig-Horner reaction of α-diketone was developed.
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