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Transient Selective Vitamin B_12 Malabsorption in an Adult

1964; American College of Physicians; Volume: 60; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-60-4-665

1539-3704

Walter J. Hogan,

Folate and B Vitamins Research

Case Studies1 April 1964Transient Selective Vitamin B12 Malabsorption in an AdultWALTER J. HOGAN, M.D., KONRAD H. SOERGEL, M.D., SARA B. ARNAUD, M.D.WALTER J. HOGAN, M.D.Search for more papers by this author, KONRAD H. SOERGEL, M.D.Search for more papers by this author, SARA B. ARNAUD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-665 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcquired, isolated inability to absorb vitamin B12 in the presence of intrinsic factor and normal intestinal anatomy has not been described in the adult, in contrast to the congenital cyanocobalamin malabsorption occasionally seen in children (1). We have observed an elderly patient with a selective vitamin B12 absorption defect which disappeared spontaneously after 15 months of observation. The investigation of the mechanism of this disorder and its differentiation from known causes for isolated B12 malabsorption form the basis of this report.CASE REPORTA 64-year-old Puerto Rican male was admitted to Milwaukee County Hospital in September, 1961, with a 2-week...References1. IMERSLUND O: Idiopathic chronic megaloblastic anemia in children. Acta Paediat. (Stockholm) 49 (Supp. 119): 1, 1960. MedlineGoogle Scholar2. CHERNISHHELMERFOUTSKOHLSTAEDT SMOMPJKG: The effect of intrinsic factor on the absorption of vitamin B-12 in older people. Amer. J. Clin. Nutr. 5: 651, 1957. CrossrefMedlineGoogle Scholar3. GLASSBOYDSTEPHANSONJONES GBLJLEL: Metabolic interrelations between intrinsic factor and vitamin B-12. III. B-12 absorption at varied intrinsic factor doses. Proc. Soc. Exp. Biol. Med. 88: 1, 1955. CrossrefMedlineGoogle Scholar4. 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JEFFRIESHOSKINSSLEISENGER GHDWMH: Antibody to intrinsic factor in serum from patients with pernicious anemia. J. Clin. Invest. 41: 1106, 1962. CrossrefMedlineGoogle Scholar40. LEARHARRISCASTLEFLEMING AAJWWBEM The serum vitamin B-12 concentration in pernicious anemia. J. Lab. Clin. Med. 44: 715, 1954. MedlineGoogle Scholar41. GORDIN R: Vitamin B-12 absorption in corticosteroid-treated pernicious anemia. Acta Med. Scand. 164: 159, 1959. CrossrefMedlineGoogle Scholar42. OSTERGAARD KRISTENSENTHORKILD HPF: Effect of prednisone on B-12 absorption in pernicious anemia. Acta Med. Scand. 166: 249, 1960. CrossrefMedlineGoogle Scholar43. SHEEHYBAGGSPEREZ-SANTIAGOFLOCH TWBEMH: Prognosis of tropical sprue— a study of the effect of folic acid on the intestinal aspects of acute and chronic sprue. Ann. Intern. Med. 57: 892, 1962. LinkGoogle Scholar44. OXENHORNESTRENWASSERMANADLERSBERG SSLRD: Malabsorption syndrome: Intestinal absorption of vitamin B-12. Ann. Intern. Med. 48: 30, 1958. LinkGoogle Scholar45. Sheehy TW PERSONAL COMMUNICATION: M.D. Google Scholar46. HERBERT V: The Megaloblastic Anemias. Grune & Stratton, New York, 1959, p. 36. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, WisconsinFrom the Department of Medicine, Marquette University School of Medicine and Milwaukee County General Hospital, Milwaukee, Wisconsin.This work was supported by Public Health Service Research Career Development Award AM-K316.605 and training grant 2 T1-AM 5162-06, Institute of Arthritis and Metabolic Diseases, National Institutes of Health, and Public Health Service General Clinical Research Center grant 8 MO 1 FR-58-02 Bethesda, Maryland.Presented in part at the Midwestern Section Meeting, American Federation for Clinical Research, Chicago, Illinois, November 1, 1962.Requests for reprints should be addressed to Konrad H. Soergel, M.D., Assistant Professor of Medicine, Department of Gastroenterology, Milwaukee County Hospital, 8700 West Wisconsin Avenue, Milwaukee 13, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTropical Sprue in 2014: the New Face of an Old DiseaseSelektive Malabsorption von Vitamin B12, Proteinurie und Antik�rpermangelsyndrom ? ein genetischer DefektSelective Inhibition of Vitamin B12 Absorption by Para-Aminosalicylic AcidThe correction of defective vit. B.12 absorption due to anti-convulsant drugs by folic acidTRANSIENT (REVERSIBLE) MALABSORPTION OF VITAMIN B 12Acquired Selective Vitamin B12 MalabsorptionTHE BLOOD VITAMIN B 12 CONCENTRATION OF OLDER PATIENTS ADMITTED TO A NEUROLOGICAL DEPARTMENTJuvenile Pernicious Anemia 1 April 1964Volume 60, Issue 4Page: 665-672KeywordsElderlyHealth services researchHispanic peopleHospital medicineMedical servicesMegaloblastic anemiaMetabolic disordersMucous membranesPrevention, policy, and public healthResearch grants ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...