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Alu family variations in neoplasia

1991; Elsevier BV; Volume: 56; Issue: 1 Linguagem: Inglês

10.1016/0165-4608(91)90357-z

1873-4456

Leonid V. Filatov, S. E. Mamayeva, Nikolai Tomilin,

Lung Cancer Treatments and Mutations

Human chromosomes contain about one million copies of dispersed repeats of the Alu family which are distributed non-randomly. In this study we have compared the pattern of hybridization of tritiated Alu-probes on chromosomes of PHA-stimulated lymphocytes of normal donors and of non-stimulated bone marrow cells of acute leukemia patients, and found regular differences in this pattern over some chromosome bands (3q26, 8p11-p12, 14q24, 15q21, 6q22) between normal individuals and leukemia patients. These data were interpreted as indicative of somatic variation of the Alu family in acute leukemia. Possible mechanisms of the variation and the role of the Alu family in chromosome rearrangements in neoplasia are discussed.