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Diclofenac sodium (GP 45840, voltaren), a potent inhibitor of prostaglandin synthetase

1975; Elsevier BV; Volume: 24; Issue: 5 Linguagem: Inglês

10.1016/0006-2952(75)90186-0

1873-2968

Edmond C. Ku, Jong M. Wsvary, William D. Cash,

Pharmacogenetics and Drug Metabolism

Diclofenac sodium, the sodium salt of o-(2,6-dichlorophenylamino)-phenylacetic acid (GP 45840, Voltaren), is a potent inhibitor of sheep seminal vesicle prostaglandin synthetase in vitro. Like indomethacin, aspirin and certain other nonsteroidal anti-inflammatory drugs, it acts as a competitive and irreversible inhibitor. It is suggested that diclofenac sodium exerts most of its pharmacological effects via inhibition of prostaglandin synthetase.