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Clinical significance of prior hepatitis B virus infection in patients with hepatitis C virus-related hepatocellular carcinoma

1999; Wiley; Volume: 86; Issue: 5 Linguagem: Inglês

10.1002/(sici)1097-0142(19990901)86

1097-0142

S Kubo, S Nishiguchi, Kazuhiro Hirohashi, Hiromu Tanaka, Tadashi Tsukamoto, Hiroyuki Hamba, Taichi Shuto, Takatsugu Yamamoto, Takashi Ikebe, Hiroaki Kinoshita,

Hepatocellular Carcinoma Treatment and Prognosis

The effect of prior hepatitis B virus (HBV) infection on the clinicopathologic findings for patients with hepatitis C virus (HCV) RNA and hepatocellular carcinoma (HCC) is still unclear.Of 59 patients who underwent liver resection for HCV-related HCC (</=2.0 cm in greatest dimension) without metastases between 1990 and 1997, 38 patients had anti-HB core antibody (anti-HBc) and did not have HB surface antigen in their sera (Group 1). Their clinicopathologic findings and outcomes after surgery were compared with those of the remaining 22 patients without anti-HBc (Group 2).The proportion of well-differentiated HCC was significantly lower in Group 1 than in Group 2 (P = 0.0214). The percentage of patients with cirrhosis was significantly lower in Group 1 than in Group 2 (P = 0.0228). The cumulative survival rate was significantly lower in Group 1 than in Group 2 (P = 0.0224). The risk ratio of anti-HBc for shorter survival time was 3.817.HCC more often developed before cirrhosis in patients with HCV RNA and anti-HBc than in patients positive for HCV RNA alone. Prior HBV infection was a risk factor for poor outcome after liver resection for patients infected with HCV.