Multiple Memory Deficits in Patients With Multiple Sclerosis
1988; American Medical Association; Volume: 45; Issue: 6 Linguagem: Inglês
10.1001/archneur.1988.00520300025012
ISSN1538-3687
AutoresIrene Litvan, Jordan Grafman, Pere Vendrell, Martinez Jm, Carme Junqué, Vendrell Jm, Barraquer-Bordas Jl,
Tópico(s)Multiple Sclerosis Research Studies
ResumoSome patients with multiple sclerosis (MS) demonstrate impaired memory. A group of 16 patients with MS who were mildly to moderately affected (Kurtzke Expanded Disability Status Scale Score = 3.8) were studied, and they were compared with a matched control group on tests of "working memory." The working memory system was explored by evaluating the amount of information that can temporarily be held in a buffer system during encoding. Results indicated that patients with MS have difficulty in processing information at the level of a hypothesized articulatory loop in working memory. This deficit was correlated with their retrieval of verbal information from long-term memory, as well as how accurately they processed verbal information presented at a rapid rate. There was no significant relationship between ratings of MS severity or number of plaques visualized on magnetic resonance imaging scans and the degree of working memory deficit.
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