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2-Phenyl-4-quinolinecarboxamides: A Novel Class of Potent and Selective Non-Peptide Competitive Antagonists for the Human Neurokinin-3 Receptor

1996; American Chemical Society; Volume: 39; Issue: 12 Linguagem: Inglês

10.1021/jm9602423

1520-4804

Giuseppe Giardina, Henry M. Sarau, Carlo Farina, Andrew D. Medhurst, Mario Grugni, James J. Foley, Luca F. Raveglia, Dulcie B. Schmidt, Roberto Rigolio, Marco Vassallo, Vittorio Vecchietti, Douglas W.P. Hay,

Chemical Synthesis and Analysis

ADVERTISEMENT RETURN TO ISSUELetterNEXT2-Phenyl-4-quinolinecarboxamides: A Novel Class of Potent and Selective Non-Peptide Competitive Antagonists for the Human Neurokinin-3 ReceptorGiuseppe A. M. Giardina, Henry M. Sarau, Carlo Farina, Andrew D. Medhurst, Mario Grugni, James J. Foley, Luca F. Raveglia, Dulcie B. Schmidt, Roberto Rigolio, Marco Vassallo, Vittorio Vecchietti, and Douglas W. P. HayView Author Information Department of Chemistry, SmithKline Beecham S.p.A., Via Zambeletti, 20021 Baranzate, Milano, Italy, Department of Pulmonary Pharmacology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406-0939, and Department of Neurology Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, England CM19 5AW Cite this: J. Med. Chem. 1996, 39, 12, 2281–2284Publication Date (Web):June 7, 1996Publication History Received27 March 1996Published online7 June 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jm9602423https://doi.org/10.1021/jm9602423rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views357Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antagonists,Quinolines,Receptors,Screening assays,Selectivity Get e-Alerts