Voltar
Artigo Revisado por pares
BIBTEX RIS

Time-dependent inactivation of steroid C17(20) lyase by 17β-cyclopropyl ether-substituted steroids

1996; Elsevier BV; Volume: 6; Issue: 1 Linguagem: Inglês

10.1016/0960-894x(95)00566-c

ISSN

1464-3405

Autores

Michael R. Angelastro, Angela L. Marquart, Philip M. Weintraub, Cynthia A. Gates, Marie E. Laughlin, Thomas R. Blohm, Norton P. Peet,

Tópico(s)

Estrogen and related hormone effects

Resumo

Androstenes bearing a cyclopropyl group attached to the C-17β position with a heteroatom linker, designed as mechanism-based inhibitors of steroid C17(20) lyase, were found to be potent, time-dependent inhibitors of this enzyme.

Referência(s)