Increased ethanol toxicity in old rats: Changes in LD50, in vivo and in vitro metabolism, and liver alcohol dehydrogenase activity
1970; Elsevier BV; Volume: 16; Issue: 3 Linguagem: Inglês
10.1016/0041-008x(70)90077-3
ISSN1096-0333
AutoresGünnar Wiberg, H. L. Trenholm, Blake B. Coldwell,
Tópico(s)Peroxisome Proliferator-Activated Receptors
ResumoOld rats (10–12 months old) were significantly more susceptible to acute ethanol poisoning than young adult rats (3–4 months old). The LD50 in young rats was 10.6 (po) and 6.71 (ip) g/kg compared to 7.06 (po) and 5.10 (ip) g/kg in the older animals. The slopes of the dose-response lines were very steep and the LD100 dose in the old animals was always substantially less than the LD0 in the young rats. Following a single ip dose of 3 g/kg, the brain and blood ethanol levels were significantly higher in the older animals and decreased at a slower rate. The decay profiles for acetaldehyde and acetone in blood and brain were more complex. Liver slices taken from older rats metabolized ethanol at a slower rate per gram of tissue than did slices from younger animals. The alcohol dehydrogenase levels per gram of tissue were significantly higher in the 1-year-old rats, and the total liver alcohol dehydrogenase activity was 3-fold greater.
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