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INTEGRATIVE ASSESSMENT OF BRAIN AND COGNITIVE FUNCTION IN POST-TRAUMATIC STRESS DISORDER

2005; Imperial College Press; Volume: 04; Issue: 01 Linguagem: Inglês

10.1142/s0219635205000719

1757-448X

MELINDA D. VELTMEYER, C. Richard Clark, Alexander C. McFarlane, Kim L. Felmingham, Richard A. Bryant, Evian Gordon,

Anesthesia and Neurotoxicity Research

Journal of Integrative NeuroscienceVol. 04, No. 01, pp. 145-159 (2005) No AccessINTEGRATIVE ASSESSMENT OF BRAIN AND COGNITIVE FUNCTION IN POST-TRAUMATIC STRESS DISORDERMELINDA D. VELTMEYER, C. RICHARD CLARK, ALEXANDER C. McFARLANE, KIM L. FELMINGHAM, RICHARD A. BRYANT, and EVIAN GORDONMELINDA D. VELTMEYERCognitive Neuroscience Laboratory and School of Psychology, Flinders University of South Australia, Adelaide, SA 5042, AustraliaGPO Box 2100, Adelaide, South Australia. 5001, AustraliaCorresponding author., C. RICHARD CLARKCognitive Neuroscience Laboratory and School of Psychology, Flinders University, Adelaide, SA 5042, Australia, ALEXANDER C. McFARLANEDepartment of Psychiatry, The University of Adelaide, Queen Elizabeth Hospital, Woodville, SA 5011, Australia, KIM L. FELMINGHAMThe Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia, RICHARD A. BRYANTSchool of Psychology, University of New South Wales, NSW 2052, Australia, and EVIAN GORDONThe Brain Resource Company and the Brain Resource International Database, Ultimo, NSW 2007, AustraliaConvenor, Integrative Neuroscience, Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, AustraliaDiscipline of Psychological Medicine, University of Sydney, NSW 2006, Australiahttps://doi.org/10.1142/S0219635205000719Cited by:41 Previous AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractThe present study combined neuropsychological and electrophysiological measures to obtain a comprehensive profile of the everyday attentional and memory dysfunction reported in PTSD. The event-related potential (ERP) literature has consistently found abnormalities in late components (N2, P3) reflecting working memory (WM) function. However, the neuropsychological profile reported in the literature has considerable variation. The present study examined ERP activity in 33 PTSD participants and matched controls during a standard two-tone auditory oddball task. Neuropsychological assessment was carried out using a task battery assessing a wide range of cognitive functions. Consistent with previous work, the PTSD group showed delayed N2 latency and reduced P3 target amplitude, together with slower and less accurate target detection. Scalp topography provided evidence of widespread abnormality during WM function, but with strongest effects broadly over the left hemisphere. Neuropsychological testing found concomitant difficulties on factorial measures of verbal memory retention/access and sustained attention but enhanced performance on measures of immediate recall. 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Hamburger et al.1 Apr 2006 | Clinical Breast Cancer, Vol. 7, No. 1INTEGRATIVE ASSESSMENT OF BRAIN FUNCTION IN PTSD: BRAIN STABILITY AND WORKING MEMORYMELINDA D. VELTMEYER, ALEXANDER C. McFARLANE, RICHARD A. BRYANT, THERESE MAYO, EVIAN GORDON, and C. RICHARD CLARK21 November 2011 | Journal of Integrative Neuroscience, Vol. 05, No. 01 Recommended Vol. 04, No. 01 Metrics History Received 7 February 2005 Revised 21 February 2005 KeywordsERPsPTSDneuropsychologyP3, N2working memoryPDF download